Schleef R R, Kenney D M, Shepro D
Thromb Haemost. 1979 Apr 23;41(2):329-36.
Concentrations of sodium chloride up to 3 M increase the time necessary for the clot formation from Limulus amebocyte lysate (LAL) induced with endotoxin. Sodium chloride at a concentration of 4 M prevents clot formation by either precipitation or denaturation of procoagulase. The time necessary for the activation of procoagulase by endotoxin is increased by a change in the sodium chloride concentration from 0.15 M to 0.588 M. No effect on the proteolytic phase or the polymerization phase of the clotting reaction is detected by the increase in sodium chloride concentration from 0.15 M to 0.588 M. The authors conclude that increased sodium chloride concentrations may aid the isolation of procoagulase.
高达3M的氯化钠浓度会延长由内毒素诱导的鲎变形细胞溶解物（LAL）形成凝块所需的时间。浓度为4M的氯化钠会通过前凝血酶原的沉淀或变性来阻止凝块形成。将氯化钠浓度从0.15M改变至0.588M会延长内毒素激活前凝血酶原所需的时间。将氯化钠浓度从0.15M提高至0.588M未检测到对凝血反应的蛋白水解阶段或聚合阶段有影响。作者得出结论，氯化钠浓度升高可能有助于前凝血酶原的分离。
