假羊肚菌毒素鹿花菌素所致的肝损伤。
Liver injury by the false morel poison gyromitrin.
作者信息
Braun R, Greeff U, Netter K J
出版信息
Toxicology. 1979 Feb;12(2):155-63. doi: 10.1016/0300-483x(79)90042-8.
After oral application of the mushroom poison gyromitrin a time and dose dependent decrease of cytochrome P-450 was found in rat liver microsomes. The maximal decrease to about 50-60% of the control (after 200 mg/kg, 80% of LD50) was observed 8-12h after application, a normalization after 48 h. The inhibition of cytochrome P-450 mediated metabolism of aminopyrine and p-nitroanisole corresponds to the decrease of cytochrome P-450. The specific activity of cytochrome P-450 remains unchanged while that of cytochrome P-448 is decreased as shown by means of the metabolism of ethoxycoumarin or ethoxyresorufin. Comparable results were obtained after application of N-methyl-N-formylhydrazine (MFH) which is formed from gyromitrin rapidly by hydrolysis. An attack on the endoplasmatic membrane with a stimulation of lipid peroxidation is discussed.
经口给予蘑菇毒素鹿花菌素后，在大鼠肝微粒体中发现细胞色素P - 450呈时间和剂量依赖性降低。给药后8 - 12小时观察到最大降幅约为对照的50 - 60%（200mg/kg后，为半数致死量的80%），48小时后恢复正常。细胞色素P - 450介导的氨基比林和对硝基苯甲醚代谢的抑制与细胞色素P - 450的降低相对应。细胞色素P - 450的比活性保持不变，而细胞色素P - 448的比活性降低，这通过乙氧香豆素或乙氧试卤灵的代谢得以证明。快速水解鹿花菌素形成的N - 甲基 - N - 甲酰肼（MFH）给药后获得了类似结果。讨论了对内质膜的攻击以及脂质过氧化的刺激作用。
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