Holland R I, Hongslo J K
Acta Pharmacol Toxicol (Copenh). 1979 May;44(5):354-8. doi: 10.1111/j.1600-0773.1979.tb02344.x.
Fluoride decreased the initial uptake of 2-aminoisobutyric acid (AIB) in LS cells only in high (supralethal) concentrations and after several hours of exposure. The steady state level of AIB seemed somewhat more sensitive as it was halved after 23 hours exposure to 6 mM-NaF. The cellular levels of some natural amino acids were also reduced by fluoride. However, cells resistant to fluoride showed equally lowered levels of amino acids, indicating that the observed effect of fluoride on cellular amino acid levels may be of little importance.
氟化物仅在高（超致死）浓度且暴露数小时后，才会降低LS细胞中2-氨基异丁酸（AIB）的初始摄取量。AIB的稳态水平似乎更敏感一些，因为在暴露于6 mM氟化钠23小时后，其稳态水平减半。一些天然氨基酸的细胞水平也会因氟化物而降低。然而，对氟化物有抗性的细胞显示出同样降低的氨基酸水平，这表明所观察到的氟化物对细胞氨基酸水平的影响可能不太重要。
