Holland R I
Acta Pharmacol Toxicol (Copenh). 1979 Oct;45(4):302-5. doi: 10.1111/j.1600-0773.1979.tb02397.x.
DNA synthesis in isolated nuclei from both fluoride sensitive and resistant LS cells was inhibited by fluoride at and above 3 mM. These fluoride concentrations also had an inhibitory effect on DNA synthesis in intact sensitive cells, but not in resistant cells. Due to previous findings that the intracellular fluoride concentration in the sensitive cells is only 30-40% of the extracellular, it is suggested that inhibition of DNA synthesis in intact cells is secondary to the inhibitory effect on protein synthesis.
在浓度为3 mM及以上时，氟化物会抑制氟化物敏感型和抗性LS细胞分离细胞核中的DNA合成。这些氟化物浓度对完整的敏感细胞中的DNA合成也有抑制作用，但对抗性细胞没有影响。鉴于之前的研究结果表明，敏感细胞内的氟化物浓度仅为细胞外的30%-40%，因此有人提出，完整细胞中DNA合成的抑制是蛋白质合成抑制的继发效应。
