Holland R I, Hongslo J K
Acta Pharmacol Toxicol (Copenh). 1978 Sep;43(3):240-5. doi: 10.1111/j.1600-0773.1978.tb02260.x.
Long-term (several years) exposure to fluoride induced decreased production of lactate in cultured, fluoride resistant LS cells. In intact, sensitive cells, 6 mM NaF had no effect on glycolysis, whereas in homogenates, from both resistant and sensitive cells, lactate production was blocked by 6 mM NaF, indicating the cell membrane to be a barrier to fluoride. A lower intracellular rather than extracellular fluoride concentration was found in the sensitive cell with a ratio of 0.4, whereas fluoride resistant cells excluded fluoride from their intracellular milieu.
长期（数年）暴露于氟化物会导致培养的耐氟LS细胞中乳酸生成减少。在完整的敏感细胞中，6 mM氟化钠对糖酵解没有影响，而在耐氟和敏感细胞的匀浆中，6 mM氟化钠会阻断乳酸生成，这表明细胞膜是氟化物的一道屏障。在敏感细胞中发现细胞内氟化物浓度低于细胞外，比例为0.4，而耐氟细胞则将氟化物排除在细胞内环境之外。
