Kannel W B, Feinleib M, McNamara P M, Garrison R J, Castelli W P
Am J Epidemiol. 1979 Sep;110(3):281-90. doi: 10.1093/oxfordjournals.aje.a112813.
The Framingham Heart Study (FHS) was started in 1948 as a prospective investigation of cardiovascular disease in a cohort of adult men and women. Continuous surveillance of this sample of 5209 subjects has been maintained through biennial physical examinations. In 1971 examinations were begun on the children of the FHS cohort. This study, called the Framingham Offspring Study (FOS), was undertaken to expand upon knowledge of cardiovascular disease, particularly in the area of familial clustering of the disease and its risk factors. This report reviews the sampling design of the FHS and describes the nature of the FOS sample. The FOS families appear to be of typical size and age structure for families with parents born in the late 19th or early 20th century. In addition, there is little evidence that coronary heart disease (CHD) experience and CHD risk factors differ in parents of those who volunteered for this study and the parents of those who did not volunteer.
弗明汉心脏研究（FHS）始于1948年，是对一组成年男性和女性心血管疾病进行的前瞻性调查。通过每两年一次的体格检查，对这5209名受试者的样本进行持续监测。1971年开始对FHS队列的子女进行检查。这项研究称为弗明汉后代研究（FOS），旨在扩展对心血管疾病的认识，特别是在该疾病及其危险因素的家族聚集方面。本报告回顾了FHS的抽样设计，并描述了FOS样本的性质。FOS家庭在父母出生于19世纪末或20世纪初的家庭中，似乎具有典型的规模和年龄结构。此外，几乎没有证据表明，参与这项研究的志愿者的父母与未参与志愿者的父母在冠心病经历和冠心病危险因素方面存在差异。
