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1
Susceptibility of phosphonoformic acid-resistant herpes simplex virus variants to arabinosylnucleosides and aphidicolin.膦甲酸耐药性单纯疱疹病毒变异体对阿糖核苷和阿非科林的敏感性
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2
Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus.单纯疱疹病毒阿拉伯糖腺嘌呤抗性突变体对其他抗病毒药物的敏感性以及药物超敏突变在DNA聚合酶基因座上的定位。
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3
Herpes simplex virus mutants resistant to arabinosyladenine in the presence of deoxycoformycin.在脱氧助间型霉素存在的情况下对阿糖腺苷耐药的单纯疱疹病毒突变体
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4
The sensitivity of acyclovir-resistant mutants of herpes simplex virus to other antiviral drugs.单纯疱疹病毒的阿昔洛韦耐药突变体对其他抗病毒药物的敏感性。
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5
Combined interaction of antiherpes substances and interferon beta on the multiplication of herpes simplex virus.抗疱疹物质与β干扰素对单纯疱疹病毒增殖的联合相互作用
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6
Altered sensitivity to antiviral drugs of herpes simplex virus isolates from a patient with the acquired immunodeficiency syndrome.从一名获得性免疫缺陷综合征患者分离出的单纯疱疹病毒对抗病毒药物的敏感性改变。
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7
Comparison of the effects of arabinosyladenine, arabinosylhypoxanthine, and arabinosyladenine 5'-monophosphate against herpes simplex virus, varicella-zoster virus, and cytomegalovirus with their effects on cellular deoxyribonucleic acid synthesis.阿糖腺苷、阿糖次黄嘌呤和阿糖腺苷5'-单磷酸对单纯疱疹病毒、水痘-带状疱疹病毒和巨细胞病毒的作用及其对细胞脱氧核糖核酸合成的作用的比较。
Antimicrob Agents Chemother. 1981 Jan;19(1):170-8. doi: 10.1128/AAC.19.1.170.
8
Single mutations at many sites within the DNA polymerase locus of herpes simplex viruses can confer hypersensitivity to aphidicolin and resistance to phosphonoacetic acid.单纯疱疹病毒DNA聚合酶基因座内许多位点的单突变可导致对阿非科林超敏并对膦甲酸耐药。
J Gen Virol. 1984 Jan;65 ( Pt 1):1-17. doi: 10.1099/0022-1317-65-1-1.
9
Effect of eight antiviral drugs on the reactivation of herpes simplex virus in explant cultures of latently infected mouse trigeminal ganglia.八种抗病毒药物对潜伏感染小鼠三叉神经节外植体培养物中单纯疱疹病毒再激活的影响。
J Invest Dermatol. 1984 Nov;83(5):344-6. doi: 10.1111/1523-1747.ep12264450.
10
Biochemical and genetic analysis of acyclovir-resistant mutants of herpes simplex virus type 1.1型单纯疱疹病毒阿昔洛韦耐药突变体的生化与遗传学分析
Am J Med. 1982 Jul 20;73(1A):351-60. doi: 10.1016/0002-9343(82)90122-x.

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Viral DNA polymerase structures reveal mechanisms of antiviral drug resistance.病毒 DNA 聚合酶结构揭示了抗病毒药物耐药性的机制。
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2
Mechanism of anti-human immunodeficiency virus activity of beta-D-6-cyclopropylamino-2',3'-didehydro-2',3'-dideoxyguanosine.β-D-6-环丙氨基-2',3'-二脱氢-2',3'-二脱氧鸟苷抗人免疫缺陷病毒活性的机制
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3
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4
Genetic characterization of the vaccinia virus DNA polymerase: cytosine arabinoside resistance requires a variable lesion conferring phosphonoacetate resistance in conjunction with an invariant mutation localized to the 3'-5' exonuclease domain.痘苗病毒DNA聚合酶的遗传特征：阿糖胞苷抗性需要一个可变损伤与定位于3'-5'核酸外切酶结构域的一个不变突变共同作用，以赋予膦甲酸抗性。
J Virol. 1993 Jul;67(7):4323-36. doi: 10.1128/JVI.67.7.4323-4336.1993.
5
Antiviral therapy in human immunodeficiency virus infections. Current status (Part II).人类免疫缺陷病毒感染中的抗病毒治疗。现状（第二部分）
Drugs. 1993 May;45(5):637-53. doi: 10.2165/00003495-199345050-00002.
6
Susceptibility of vaccine strains of varicella-zoster virus to antiviral compounds.水痘-带状疱疹病毒疫苗株对抗病毒化合物的敏感性。
Antimicrob Agents Chemother. 1984 Apr;25(4):417-21. doi: 10.1128/AAC.25.4.417.
7
Mutations in the herpes simplex virus DNA polymerase gene conferring hypersensitivity to aphidicolin.单纯疱疹病毒DNA聚合酶基因中赋予对阿非科林超敏反应的突变。
Nucleic Acids Res. 1983 Aug 11;11(15):5287-97. doi: 10.1093/nar/11.15.5287.
8
Susceptibility to other antiherpes drugs of pathogenic variants of herpes simplex virus selected for resistance to acyclovir.单纯疱疹病毒对阿昔洛韦产生耐药性的致病变体对其他抗疱疹药物的敏感性。
Antimicrob Agents Chemother. 1986 May;29(5):894-8. doi: 10.1128/AAC.29.5.894.
9
Sequence and mapping analyses of the herpes simplex virus DNA polymerase gene predict a C-terminal substrate binding domain.单纯疱疹病毒DNA聚合酶基因的序列和定位分析预测了一个C端底物结合结构域。
Proc Natl Acad Sci U S A. 1985 Dec;82(23):7969-73. doi: 10.1073/pnas.82.23.7969.
10
Mutually exclusive inhibition of herpesvirus DNA polymerase by aphidicolin, phosphonoformate, and acyclic nucleoside triphosphates.阿非科林、膦甲酸和无环核苷三磷酸对疱疹病毒DNA聚合酶的相互排斥抑制作用。
Antimicrob Agents Chemother. 1985 Apr;27(4):445-8. doi: 10.1128/AAC.27.4.445.

本文引用的文献

1
Herpes simplex virus variants restraint to high concentrations of acyclovir exist in clinical isolates.临床分离株中存在对高浓度阿昔洛韦耐药的单纯疱疹病毒变种。
Antimicrob Agents Chemother. 1982 Jul;22(1):71-7. doi: 10.1128/AAC.22.1.71.
2
Characterization of the DNA polymerases induced by a group of herpes simplex virus type I variants selected for growth in the presence of phosphonoformic acid.对一组在膦甲酸存在下选择用于生长的单纯疱疹病毒I型变体诱导产生的DNA聚合酶的特性分析。
J Biol Chem. 1982 Sep 10;257(17):10251-60.
3
Mutations in the herpes simplex virus DNA polymerase gene can confer resistance to 9-beta-D-arabinofuranosyladenine.单纯疱疹病毒DNA聚合酶基因的突变可赋予对9-β-D-阿拉伯呋喃糖基腺嘌呤的抗性。
J Virol. 1982 Mar;41(3):909-18. doi: 10.1128/JVI.41.3.909-918.1982.
4
Acyclovir-resistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities.1型单纯疱疹病毒的阿昔洛韦耐药突变体表现出DNA聚合酶改变或阿昔洛韦磷酸化活性降低。
J Virol. 1981 Dec;40(3):936-41. doi: 10.1128/JVI.40.3.936-941.1981.
5
Physical mapping of drug resistance mutations defines an active center of the herpes simplex virus DNA polymerase enzyme.耐药性突变的物理图谱确定了单纯疱疹病毒DNA聚合酶的活性中心。
J Virol. 1981 Sep;39(3):746-57. doi: 10.1128/JVI.39.3.746-757.1981.
6
Altered substrate specificity of herpes simplex virus thymidine kinase confers acyclovir-resistance.单纯疱疹病毒胸苷激酶底物特异性的改变赋予了对阿昔洛韦的抗性。
Nature. 1981 Jan 1;289(5793):81-3. doi: 10.1038/289081a0.
7
Mechanism of inhibition of herpes simplex virus and vaccinia virus DNA polymerases by aphidicolin, a highly specific inhibitor of DNA replication in eucaryotes.抑霉素（一种真核生物中DNA复制的高度特异性抑制剂）对单纯疱疹病毒和痘苗病毒DNA聚合酶的抑制机制
J Virol. 1980 Nov;36(2):457-64. doi: 10.1128/JVI.36.2.457-464.1980.
8
Isolation and characterization of acyclovir-resistant mutants of herpes simplex virus.单纯疱疹病毒阿昔洛韦耐药突变体的分离与鉴定
J Gen Virol. 1980 Jul;49(1):115-24. doi: 10.1099/0022-1317-49-1-115.
9
Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1.两个不同的基因座赋予单纯疱疹病毒1型对阿昔洛韦的抗性。
Proc Natl Acad Sci U S A. 1980 Apr;77(4):2265-9. doi: 10.1073/pnas.77.4.2265.
10
Effect of combinations of acyclovir with vidarabine or its 5'-monophosphate on herpes simplex viruses in cell culture and in mice.阿昔洛韦与阿糖腺苷或其5'-单磷酸酯联合使用对细胞培养物和小鼠中单纯疱疹病毒的影响。
Antimicrob Agents Chemother. 1982 Sep;22(3):499-507. doi: 10.1128/AAC.22.3.499.

膦甲酸耐药性单纯疱疹病毒变异体对阿糖核苷和阿非科林的敏感性

Susceptibility of phosphonoformic acid-resistant herpes simplex virus variants to arabinosylnucleosides and aphidicolin.

作者信息

Bastow K F, Derse D D, Cheng Y C

出版信息

Antimicrob Agents Chemother. 1983 Jun;23(6):914-7. doi: 10.1128/AAC.23.6.914.

DOI:10.1128/AAC.23.6.914
PMID:6311091
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC185003/
Abstract

A plaque-reduction assay was used to examine the susceptibility of five phosphonoformic acid-resistant variants of herpes simplex virus type 1 to arabinosylnucleosides and aphidicolin. These viruses were cross-resistant to arabinosylhypoxanthine and to arabinosyladenine when tested in the absence of deoxycoformycin, a deaminase inhibitor. In the presence of deoxycoformycin, no cross-resistance between arabinosyladenine and phosphonoformic acid was observed. The two variants tested were cross-resistant to arabinosylthymine, and all five variants were collaterally susceptible to aphidicolin inhibition.

摘要

采用蚀斑减少试验检测了5株1型单纯疱疹病毒膦甲酸耐药变异株对阿糖核苷和阿非科林的敏感性。当在无脱氨霉素（一种脱氨酶抑制剂）的情况下进行检测时，这些病毒对阿糖次黄嘌呤和阿糖腺嘌呤存在交叉耐药性。在有脱氨霉素存在的情况下，未观察到阿糖腺嘌呤与膦甲酸之间存在交叉耐药性。所检测的两株变异株对阿糖胸腺嘧啶存在交叉耐药性，并且所有5株变异株对阿非科林抑制作用均呈现并行敏感性。