Tani M, Kamihata S
Arch Dermatol Res. 1979 May 29;265(1):105-10. doi: 10.1007/BF00412707.
Ultracytochemical demonstration of acid phosphatase (ACPase) activity during the developing of intraepidermal eccrine sweat duct (eccrine acrosyringium) of human embryos was performed in order to elucidate the functional relationship between multivesicular dense bodies and intracellular cavities formed within the inner cells of eccrine sweat apparatus anlagen and to clarify the ultracytochemical characteristics of the multivesicular dense bodies. ACPase activity was characteristically detected in the unit membrane structures of small pinched-off vesicles within cavities and of immature microvilli lining these cavities as well as in those of multivesicular dense bodies. These findings give strong support to the theory that the multivesicular dense bodies are lysosomes and through their action the autolytic formation of intraepidermal eccrine sweat duct is carried out.
为了阐明多囊致密小体与外泌汗腺原基内细胞形成的细胞内腔之间的功能关系，并明确多囊致密小体的超微细胞化学特征，对人类胚胎表皮内小汗腺导管（小汗腺顶段）发育过程中的酸性磷酸酶（ACPase）活性进行了超微细胞化学显示。在腔内小的缢断小泡、衬于这些腔的未成熟微绒毛以及多囊致密小体的单位膜结构中均检测到特征性的ACPase活性。这些发现有力地支持了以下理论：多囊致密小体是溶酶体，通过其作用实现表皮内小汗腺导管的自溶形成。
