幼猪的胃排空

Gastric emptying in young pigs.

作者信息

Ochia B A

出版信息

J Physiol. 1973 Sep;233(3):467-80. doi: 10.1113/jphysiol.1973.sp010318.

DOI:10.1113/jphysiol.1973.sp010318

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1350587/

Abstract

Gastric emptying in young pigs has been studied by using a serial test meal procedure.2. Phenol red was used as a reference substance. In acute experiments the recovery of phenol red from the stomach with the pylorus occluded was 94.8 +/- 2.2 (S.E.)% of that introduced.3. Gastric emptying was examined in seven fasted conscious pigs provided with a chronic gastric cannula. After emptying the stomach 500 ml. of a liquid meal containing 20 g citrus pectin, 35.0 g sucrose and 100 mg phenol red made up to 1 l. was introduced. After 5-60 min the meal was withdrawn, the volume of meal that had left the stomach was assessed from the recovery of phenol red and the secretion of gastric juice was calculated from the dilution of phenol red and the rate of emptying. After an initial very rapid outflow, the rate of emptying fell with time, as did the rate of secretion.4. In three pigs 200, 400, 600 or 800 ml. meal was introduced into the stomach and the stomach was emptied 20 min later. The rate of gastric emptying varied directly with the volume of meal introduced.5. Atropine sulphate, 0.5 mg/kg body weight, injected I.M. 30 min before the test, greatly inhibited gastric emptying and secretion.

摘要

采用连续试餐法对幼猪的胃排空进行了研究。
以酚红作为参考物质。在急性实验中，幽门闭塞时胃内酚红的回收率为注入量的94.8±2.2（标准误）%。
对7只装有慢性胃插管的禁食清醒猪进行胃排空检查。胃排空后，向胃内注入1升含有20克柑橘果胶、35.0克蔗糖和100毫克酚红的流质餐。5 - 60分钟后取出餐食，根据酚红的回收率评估离开胃的餐食量，并根据酚红的稀释度和排空速率计算胃液分泌量。最初流出速度非常快，之后排空速率随时间下降，分泌速率也随之下降。
给3只猪胃内分别注入200、400、600或800毫升餐食，20分钟后将胃排空。胃排空速率与注入的餐食量成正比。
在试验前30分钟肌肉注射0.5毫克/千克体重的硫酸阿托品，可显著抑制胃排空和分泌。