Steel G G, Adams K, Peckham M J
Br J Radiol. 1979 Sep;52(621):741-7. doi: 10.1259/0007-1285-52-621-741.
C57Bl mice were treated with thoracic irradiation to doses in the range 12.0 to 18.9 gray. Few deaths were observed in the period 80--160 days after irradiation (an end-point of lung damage used by other investigators) and the median survival times ranged from 200 to 310 days. CBA mice treated under identical conditions predominantly died between 80--160 days and it is therefore concluded that C57Bl mice show unusually prolonged survival following this treatment. Six chemotherapeutic agents were given to C57Bl mice together with thoracic irradiation, in most cases two weeks beforehand. Adriamycin, bleomycin and cyclophosphamide enhanced the mortality of the mice. Most agents had little effect on radiation-induced skin damage.
对C57Bl小鼠进行胸部照射，剂量范围为12.0至18.9格雷。在照射后80 - 160天期间（其他研究者使用的肺损伤终点）观察到很少有死亡情况，中位生存时间为200至310天。在相同条件下处理的CBA小鼠主要在80 - 160天之间死亡，因此得出结论，C57Bl小鼠在这种处理后显示出异常延长的生存期。六种化疗药物与胸部照射一起给予C57Bl小鼠，大多数情况下是在照射前两周。阿霉素、博来霉素和环磷酰胺增加了小鼠的死亡率。大多数药物对辐射引起的皮肤损伤影响很小。
