原发性胆汁性肝硬化中植物血凝素（PHA）诱导的淋巴细胞转化及弓形虫抗体研究。细胞介导免疫受损的证据。
Phytohaemagglutinin (PHA) induced lymphocyte transformation and Toxoplasma gondii antibody studies in primary biliary cirrhosis. Evidence of impaired cell-mediated immunity.
作者信息
MacSween R N, Galbraith I, Thomas M A, Watkinson G, Ludlam G B
出版信息
Clin Exp Immunol. 1973 Sep;15(1):35-42.
Abstract
Phytohaemagglutinin (PHA) induced dose-response lymphocyte transformation has been studied in a group of patients with primary biliary cirrhosis. There is a marked reduction in responsiveness, particularly with low doses of PHA. These observations, together with the finding of a raised incidence (7%) of high titre antibody in primary biliary cirrhosis patients, are adduced as evidence of impaired cell-mediated immunity in this disease.
摘要
在一组原发性胆汁性肝硬化患者中研究了植物血凝素（PHA）诱导的剂量反应性淋巴细胞转化。反应性显著降低，尤其是低剂量PHA时。这些观察结果，连同原发性胆汁性肝硬化患者中高滴度抗体发生率升高（7%）的发现，被引为该疾病中细胞介导免疫受损的证据。
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