Lundkvist O
Cell Tissue Res. 1979 Jun 27;199(2):339-48. doi: 10.1007/BF00236143.
Morphometric methods were used at the light microscopic level to investigate the appearance of edema in the endometrial stroma of rats during estradiol-induced implantation after an experimental delay. Comparisons between blastocyst-free and blastocyst-containing sites were made at 18, 12, 16 and 24 h after injection of estradiol (h.a.e.). The development of stromal edema during implantation was found to be diphasic. First, during the initial 8--12 h.a.e., a generalized edema developed all along the uterine horns. Later, from 16 h.a.e. onwards, a local edema was present around the blastocysts. The Pontamine Blue Reaction (PBR) became visible between 20 and 24 h.a.e. The results indicate that the blastocyst is recognized by the stroma considerably before the PBR. The appearance of a local edema around the blastocysts before the PBR might be related to a slow increase in vascular permeability and/or to the increased stromal cell synthetic activity that is known to precede the PBR during early implantation.
采用形态测量学方法在光学显微镜水平研究实验性延迟后雌二醇诱导大鼠着床期间子宫内膜基质中水肿的表现。在注射雌二醇后18、12、16和24小时（h.a.e.），对无胚泡部位和含胚泡部位进行比较。发现着床期间基质水肿的发展呈双相性。首先，在注射雌二醇后的最初8 - 12小时内，子宫角全长出现全身性水肿。之后，从注射雌二醇后16小时起，胚泡周围出现局部水肿。在注射雌二醇后20至24小时可见滂胺蓝反应（PBR）。结果表明，基质在滂胺蓝反应之前很久就识别出胚泡。在滂胺蓝反应之前胚泡周围出现局部水肿可能与血管通透性的缓慢增加和/或与早期着床期间已知在滂胺蓝反应之前出现的基质细胞合成活性增加有关。
