Kaszniak A W, Garron D C, Fox J
Cortex. 1979 Jun;15(2):285-95. doi: 10.1016/s0010-9452(79)80032-5.
Seventy-eight patients suspected of dementia, 50 years of age or older and without evidence of focal cerebral lesion or systemic illness, were administered the Digit-Span Forward and Paired-Associate Learning subtests of the Wechsler Memory Scale. Computerized axial tomography, allowing a visualization and measurement of the lateral ventricles and cortical sulci, was employed to measure cerebral atrophy. Four groups were defined as follows: (1) age 50-69, without atrophy (N = 27), (2) age 50-69, with atrophy (N = 17), (3) age 70-89, without atrophy (N = 18), (4) age 70-89, with atrophy (N = 16). Results of analyses of variance indicate that Digit-Span is affected by cerebral atrophy but not by age, while Paired-Associate Learning is affected by both age and cerebral atrophy. No interaction effect between age and cerebral atrophy was found for either task. These results are discussed within the context of previous research, and implications for both models of memory and theories of the effects of cerebral atrophy in different ag groups are suggested.
78名疑似患有痴呆症的患者，年龄在50岁及以上，且无局灶性脑病变或全身性疾病证据，接受了韦氏记忆量表的数字广度顺背和成对联想学习分测验。采用计算机断层扫描技术，以可视化和测量侧脑室及脑沟，来测量脑萎缩情况。四组被定义如下：（1）50 - 69岁，无萎缩（N = 27），（2）50 - 69岁，有萎缩（N = 17），（3）70 - 89岁，无萎缩（N = 18），（4）70 - 89岁，有萎缩（N = 16）。方差分析结果表明，数字广度受脑萎缩影响，但不受年龄影响，而成对联想学习则受年龄和脑萎缩两者影响。两项任务均未发现年龄与脑萎缩之间的交互作用。这些结果在先前研究的背景下进行了讨论，并对记忆模型以及不同年龄组脑萎缩影响理论的意义提出了建议。
