Nielsen N V, Sorensen P N, Ditzel J
Diabete Metab. 1979 Jun;5(2):97-101.
In a controlled study fluorescein angiography of the retina and measurements of hemoglobin A1C were carried out in subjects with slightly abnormal two-hour glucose tolerance and controls with normal glucose tolerance. Fluorescent dots were present in 50 per cent of the series with a reduced glucose tolerance. Leakage from retinal vessels was noted in 20 per cent. In the control group fluorescent dots were present in 25 per cent, of whom none showed leakage. In neither of the series did any subject display ophthalmoscopically visible signs of diabetic retinopathy. In the subjects with abnormal glucose tolerance the mean concentration of hemoglobin A1C was 5.88% +/- 1.15 (SD) and in the control group 5.11% +/- 0.85 (SD) (P less than 0.05) . No correlation was demonstrable between the number of fluorescent dots, hemoglobin A1C and age in the group with abnormal glucose tolerance, but a relationship was noticed between a hereditary disposition to diabetes mellitus and presence of fluorescent dots. Smoking appeared not to have any influence. The result of the present study indicates that incipient retinal microvascular changes and evidence of an early breakdown of the blood-retinal barrier may be present in subjects before diabetes becomes manifest.
在一项对照研究中，对两小时糖耐量略异常的受试者以及糖耐量正常的对照组进行了视网膜荧光血管造影和糖化血红蛋白测量。糖耐量降低的受试者系列中有50%出现荧光点。20%观察到视网膜血管渗漏。对照组中25%出现荧光点，其中无一例显示渗漏。两个系列中均无受试者出现检眼镜可见的糖尿病视网膜病变体征。糖耐量异常的受试者中糖化血红蛋白的平均浓度为5.88%±1.15（标准差），对照组为5.11%±0.85（标准差）（P<0.05）。糖耐量异常组中荧光点数量、糖化血红蛋白与年龄之间无明显相关性，但注意到糖尿病遗传易感性与荧光点的存在之间存在关联。吸烟似乎没有任何影响。本研究结果表明，在糖尿病显现之前，受试者可能已存在早期视网膜微血管变化以及血视网膜屏障早期破坏的迹象。
