Soeldner J S, Christacopoulos P S, Gleason R E
Diabetes. 1976;25(2 SUPPL):903-8.
A preliminary survey has been completed using manual densitometric technics to determine the mean retinal circulation times in groups of normal controls, offspring to two diabetic parents with normal glucose tolerance (prediabetics), and offspring of two diabetic parents with abnormal glucose tolerance (chemical diabetics). Comparisons of the mean retinal circulation time showed differences between the left eye and right eye in prediabetic and chemical diabetic groups and a sex difference in both normals and prediabetics. In addition, both age and per cent ideal body weight were inversely related to the mean retinal circulation time. The levels of fasting serum cholesterol, triglyceride, and growth hormone, in many instances, also appeared to be inversely related to the mean retinal circulation time. Similarly, the degree of glucose tolerance (determined by the area under the glucose curve above baseline) was significantly inversely related to the mean retinal circulation time. The mean retinal circulation time adjusted for per cent ideal weight was analyzed separately for both right eye and left eye, and a significantly shorter mean retinal circulation time was noted, particularly in males, for prediabetics than for normal controls and for chemical diabetics than for both prediabetics and normals. Analysis of the mean retinal circulation time adjusted for age showed similar differences. It is postulated that the genetic prediabetic state with or without glucose intolerance might be associated with significant alterations of mean retinal circulation time independent of age and per cent ideal weight. It is also suggested that a number of potentially meaningful interrelationships between the degree of glucose intolerance and/or hyperlipidemia might exist and should be further quantified.
已采用手工密度测定技术完成一项初步调查，以确定正常对照组、糖耐量正常的双亲患糖尿病的后代（糖尿病前期患者）以及糖耐量异常的双亲患糖尿病的后代（化学性糖尿病患者）的平均视网膜循环时间。平均视网膜循环时间的比较显示，糖尿病前期和化学性糖尿病组的左眼和右眼之间存在差异，正常人和糖尿病前期患者中均存在性别差异。此外，年龄和理想体重百分比均与平均视网膜循环时间呈负相关。在许多情况下，空腹血清胆固醇、甘油三酯和生长激素水平似乎也与平均视网膜循环时间呈负相关。同样，糖耐量程度（由基线以上葡萄糖曲线下面积确定）与平均视网膜循环时间显著负相关。分别对右眼和左眼按理想体重百分比调整后的平均视网膜循环时间进行分析，结果发现，糖尿病前期患者的平均视网膜循环时间明显较短，尤其是男性，与正常对照组相比是这样，与糖尿病前期患者和正常对照组相比，化学性糖尿病患者的情况也是如此。对按年龄调整后的平均视网膜循环时间进行分析也显示出类似差异。据推测，无论有无糖耐量异常，遗传糖尿病前期状态可能与平均视网膜循环时间的显著改变有关，且不受年龄和理想体重百分比的影响。还表明，糖耐量异常程度和/或高脂血症之间可能存在一些潜在的有意义的相互关系，应进一步量化。
