Nielsen N V
Acta Endocrinol Suppl (Copenh). 1980;238:77-84.
Retinal fluorescein angiography was performed in 54 borderline diabetics and 23 normoglycemic controls. In 24 subjects of the borderline diabetics and 18 of the controls hemoglobin AIc, serum cholesterol, serum triglyceride, serum lipoproteins and urinary excretion of 9 plasma proteins were measured. In 50% of the borderline diabetics fluorescein angiographic dots were disclosed contrary to 25% in the controls. These findings did correlate with a hereditary pre-disposition to diabetes, but not with age and smoking habits. In the borderline diabetic group 41% had increased levels of hemoglobin AIc (greater than or equal to 6.5%) and serum cholesterol (greater than or equal to 8 mmol/l). No correlation between fluoresceinangiographic abnormalities and increased concentrations of hemoglobin AIc and serum cholesterol was present. These results are discussed with reference to previous reports of retinopathy in subjects with and without impaired glucose tolerance test and newly diagnosed overt diabetes. Subtle retinal microvascular abnormalities demonstrated by fluorescein angiography may be present in persons with moderate impaired glucose tolerance. However, the variations of the retinal fluorescein angiogram of normal individuals are at the present inadequately studied.
对54例临界糖尿病患者和23例血糖正常的对照者进行了视网膜荧光血管造影。对24例临界糖尿病患者和18例对照者测定了糖化血红蛋白、血清胆固醇、血清甘油三酯、血清脂蛋白以及9种血浆蛋白的尿排泄量。50%的临界糖尿病患者出现了荧光血管造影斑点，而对照者中这一比例为25%。这些发现与糖尿病的遗传易感性相关，但与年龄和吸烟习惯无关。在临界糖尿病组中，41%的患者糖化血红蛋白水平升高（大于或等于6.5%）以及血清胆固醇水平升高（大于或等于8 mmol/l）。荧光血管造影异常与糖化血红蛋白和血清胆固醇浓度升高之间不存在相关性。参考之前有关葡萄糖耐量试验受损和新诊断的显性糖尿病患者视网膜病变的报告对这些结果进行了讨论。荧光血管造影显示的轻微视网膜微血管异常可能存在于糖耐量中度受损的人群中。然而，目前对正常个体视网膜荧光血管造影的变化研究不足。
