培养的大鼠肝细胞对黄曲霉毒素B1和苯并(a)芘的敏感性。
Sensitivity of cultured rat hepatocytes to aflatoxin B1 and benzo(a)pyrene.
作者信息
Schaeffer W I, Chuang A H, Heintz N, Bresnick E
出版信息
In Vitro. 1979 Jun;15(6):437-40. doi: 10.1007/BF02618412.
PMID:478568
Abstract
We have tested the sensitivity of a cloned rat hepatocyte line, RL-PR-C, to aflatoxin B1 and benzo(a)pyrene as a function of population-doubling level. The cells were much more sensitive to the cytotoxic action of these agents subsequent to 230 population doublings. This sensitivity corresponded to the enhanced inducibility of aryl hydrocarbon hydroxylase activity by 3-methylcholanthrene.
摘要
我们已经测试了克隆的大鼠肝细胞系RL-PR-C对黄曲霉毒素B1和苯并(a)芘的敏感性，该敏感性是群体倍增水平的函数。在230次群体倍增后，细胞对这些试剂的细胞毒性作用更为敏感。这种敏感性与3-甲基胆蒽对芳烃羟化酶活性的诱导性增强相对应。
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