Turner R, Martin M, Schroff J, Treadway W, DeChatelet L
Inflammation. 1979 Jul;3(3):319-27. doi: 10.1007/BF00914189.
This study analyzed the neutrophils and sera of patients with rheumatoid arthritis and of normal controls. No significant differences were found in the activities of the granular enzymes beta-glucuronidase and lysozyme or the cytoplasmic enzyme lactic dehydrogenase (LDH). Normal neutrophils were found to release significant (P less than 0.05) amounts of the granular enzymes, but not of LDH in response to immunoglobulin G aggregates. There was no difference in the percent release exhibited by rheumatoid versus control neutrophils. Studies delineating the effects of rheumatoid factor sera and normal sera on aggregate-induced enzyme release revealed a significant negative correlation between the amount of rheumatoid factor in the sera and the percent release of beta-glucuronidase and lysozyme but not of LDH. These studies thus demonstrate no abnormalities in rheumatoid neutrophil or rheumatoid serum enzyme activities or in neutrophil response to immunoglobulin G aggregates. They suggest, however, that rheumatoid factor may partially inhibit the release of lysosomal enzymes, thus suppressing this important component of the rheumatoid inflammatory process.
本研究分析了类风湿性关节炎患者及正常对照者的中性粒细胞和血清。在颗粒酶β-葡萄糖醛酸酶和溶菌酶或细胞质酶乳酸脱氢酶（LDH）的活性方面未发现显著差异。发现正常中性粒细胞在受到免疫球蛋白G聚集体刺激时会释放大量（P小于0.05）的颗粒酶，但不会释放LDH。类风湿性关节炎患者与对照者的中性粒细胞释放百分比没有差异。描述类风湿因子血清和正常血清对聚集体诱导的酶释放影响的研究表明，血清中类风湿因子的量与β-葡萄糖醛酸酶和溶菌酶的释放百分比之间存在显著负相关，但与LDH的释放百分比无关。因此，这些研究表明类风湿性关节炎患者的中性粒细胞或血清酶活性以及中性粒细胞对免疫球蛋白G聚集体的反应均无异常。然而，研究表明类风湿因子可能会部分抑制溶酶体酶的释放，从而抑制类风湿性炎症过程的这一重要组成部分。
