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尿酸对类风湿性炎症和自身免疫过程体外模型的影响。

Uric acid effects on in vitro models of rheumatoid inflammatory and autoimmune processes.

作者信息

Turner R A, Pisko E J, Agudelo C A, Counts G B, Foster S L, Treadway W J

出版信息

Ann Rheum Dis. 1983 Jun;42(3):338-42. doi: 10.1136/ard.42.3.338.

DOI:10.1136/ard.42.3.338
PMID:6859966
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1001143/
Abstract

A neutrophil monolayer system was used to study the effects of uric acid on neutrophil-aggregate interactions important in rheumatoid inflammation. No effect on immunoglobulin G aggregate phagocytosis was seen, but hyperuricaemic levels of uric acid were associated with an enhancement of phagocytosis-induced release of the azurophilic granular enzyme beta-glucuronidase. A trinitrophenyl-coupled mononuclear leucocyte rheumatoid factor plaque-forming assay was utilised to study uric acid effects on polyclonal activation of immunocompetent cells. Low levels of uric acid enhanced and high levels suppressed this system. Hyperuricaemia may enhance some aspects of rheumatoid inflammation, while uric acid may modulate an important component of rheumatoid autoimmunity.

摘要

采用中性粒细胞单层系统研究尿酸对类风湿性炎症中重要的中性粒细胞聚集相互作用的影响。未观察到对免疫球蛋白G聚集物吞噬作用的影响，但高尿酸水平的尿酸与吞噬作用诱导的嗜天青颗粒酶β-葡萄糖醛酸酶释放增强有关。利用三硝基苯基偶联的单核白细胞类风湿因子斑块形成试验研究尿酸对免疫活性细胞多克隆激活的影响。低水平尿酸增强该系统，而高水平尿酸则抑制该系统。高尿酸血症可能会增强类风湿性炎症的某些方面，而尿酸可能会调节类风湿性自身免疫的一个重要组成部分。

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本文引用的文献

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STUDIES ON THE PATHOGENESIS OF RHEUMATOID JOINT INFLAMMATION. I. THE "R.A. CELL" AND A WORKING HYPOTHESIS.类风湿性关节炎症发病机制的研究。I. “类风湿性关节炎细胞”及一个可行的假说。
Ann Intern Med. 1965 Feb;62:271-80. doi: 10.7326/0003-4819-62-2-271.
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ARTIFICIAL URIC ACID CONCRETIONS AND OBSERVATIONS ON URIC ACID SOLUBILITY AND SUPERSATURATION.人工尿酸结石以及关于尿酸溶解度和过饱和的观察
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Inflammation. 1980 Mar;4(1):55-64. doi: 10.1007/BF00914103.
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Coexistent rheumatoid arthritis and tophaceous gout: a case report.类风湿关节炎与痛风石性痛风并存：一例报告
Ann Rheum Dis. 1981 Aug;40(4):427-9. doi: 10.1136/ard.40.4.427.
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Proc Soc Exp Biol Med. 1981 Oct;168(1):131-6. doi: 10.3181/00379727-168-41247.
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Use of chromium chloride as the coupling agent in a modified plaque assay. Cells producing anti-protein antibody.在改良噬菌斑测定中使用氯化铬作为偶联剂。产生抗蛋白质抗体的细胞。
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