甲基乙二醛双（脒腙）对白血病小鼠鸟氨酸脱羧酶活性的刺激作用及S-腺苷-L-甲硫氨酸脱羧酶活性的抑制作用
Stimulation of ornithine decarboxylase activity and inhibition of S-adenosyl-L-methionine decarboxylase activity in leukaemic mice by methylglyoxal bis(guanylhydrazone).
作者信息
Heby O, Sauter S, Russell D H
出版信息
Biochem J. 1973 Dec;136(4):1121-4. doi: 10.1042/bj1361121.
Abstract
Administration of methylglyoxal bis(guanylhydrazone) to leukaemic mice results in an early depression followed by a marked elevation of S-adenosyl-l-methionine decarboxylase activity. Further, there is an early prolonged increase in the activity of ornithine decarboxylase, the initial enzyme in the polyamine biosynthetic pathway. Because of the profound effects of methylglyoxal bis(guanylhydrazone) in vivo on the polyamine biosynthetic pathway, the drug can no longer be considered a specific inhibitor of spermidine synthesis.
摘要
给白血病小鼠施用甲基乙二醛双（脒腙）会导致早期活性降低，随后S-腺苷-L-甲硫氨酸脱羧酶活性显著升高。此外，鸟氨酸脱羧酶（多胺生物合成途径中的初始酶）的活性会早期持续增加。由于甲基乙二醛双（脒腙）在体内对多胺生物合成途径有深远影响，该药物不能再被视为亚精胺合成的特异性抑制剂。
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本文引用的文献
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Spermidine in Regenerating Liver: Relation to Rapid Synthesis of Ribonucleic Acid.精胺在肝脏再生中的作用：与核糖核酸的快速合成有关。
Science. 1965 Jul 23;149(3682):428-9. doi: 10.1126/science.149.3682.428.
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Polyamines and nucleic acids during development of the chick embryo.鸡胚发育过程中的多胺与核酸
Biochem J. 1965 Oct;97(1):84-8. doi: 10.1042/bj0970084.
3
CURRENT STUDIES WITH METHYLGLYOXAL-BIS(GUANYLHYDRAZONE).甲基乙二醛双（脒腙）的当前研究
Cancer Res. 1963 Sep;23:1375-89.
4
Effect of inhibition of spermidine formation on protein and nucleic acid synthesis during lymphocyte activation.抑制亚精胺形成对淋巴细胞激活过程中蛋白质和核酸合成的影响。
FEBS Lett. 1973 Feb 1;29(3):301-304. doi: 10.1016/0014-5793(73)80044-4.
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Biochim Biophys Acta. 1966 Jul 20;123(1):197-201. doi: 10.1016/0005-2787(66)90173-0.
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