甲基乙二醛双（脒腙）对大鼠肝脏和肾脏中精胺形成的抑制作用。
Inhibition of spermidine formation in rat liver and kidney by methylglyoxal bis(guanylhydrazone).
作者信息
Pegg A E
出版信息
Biochem J. 1973 Mar;132(3):537-40. doi: 10.1042/bj1320537.
Abstract
The effect of methylglyoxal bis(guanylhydrazone), a substance known to inhibit putrescine-dependent S-adenosyl-l-methionine decarboxylase, on polyamine metabolism in liver and kidney was investigated. Almost complete inhibition of the incorporation of putrescine into spermidine was obtained up to 8h after administration of 80mg of methylglyoxal bis(guanylhydrazone)/kg body wt. by intraperitoneal injection. However, by 20h after administration of the inhibitor spermidine synthesis was resumed. Considerable accumulation of putrescine occurred during this period (up to 3 times control concentrations in both tissues), but there was only a slight fall in the spermidine content. These results suggest that the putrescine-activated S-adenosyl-l-methionine decarboxylase plays an essential role in spermidine biosynthesis in rat liver and kidney, and the possibility of using methylglyoxal bis(guanylhydrazone) to study the role of polyamine synthesis in growth is discussed.
摘要
研究了甲基乙二醛双（脒腙）（一种已知可抑制腐胺依赖性S-腺苷-L-甲硫氨酸脱羧酶的物质）对肝脏和肾脏中多胺代谢的影响。通过腹腔注射给予80mg甲基乙二醛双（脒腙）/kg体重后，在长达8小时的时间内，腐胺掺入亚精胺的过程几乎完全受到抑制。然而，在给予抑制剂20小时后，亚精胺合成恢复。在此期间，腐胺大量积累（在两个组织中高达对照浓度的3倍），但亚精胺含量仅略有下降。这些结果表明，腐胺激活的S-腺苷-L-甲硫氨酸脱羧酶在大鼠肝脏和肾脏的亚精胺生物合成中起重要作用，并讨论了使用甲基乙二醛双（脒腙）研究多胺合成在生长中的作用的可能性。
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本文引用的文献
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Spermidine in Regenerating Liver: Relation to Rapid Synthesis of Ribonucleic Acid.精胺在肝脏再生中的作用：与核糖核酸的快速合成有关。
Science. 1965 Jul 23;149(3682):428-9. doi: 10.1126/science.149.3682.428.
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Polyamines and nucleic acids during development of the chick embryo.鸡胚发育过程中的多胺与核酸
Biochem J. 1965 Oct;97(1):84-8. doi: 10.1042/bj0970084.
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SPERMIDINE AND SPERMINE IN RAT TISSUES AT DIFFERENT AGES.不同年龄大鼠组织中的亚精胺和精胺
Acta Physiol Scand. 1964 Dec;62:352-8. doi: 10.1111/j.1748-1716.1964.tb10433.x.
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CURRENT STUDIES WITH METHYLGLYOXAL-BIS(GUANYLHYDRAZONE).甲基乙二醛双（脒腙）的当前研究
Cancer Res. 1963 Sep;23:1375-89.
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Studies on the biosynthetic pathway of polyamines in rat liver.大鼠肝脏中多胺生物合成途径的研究。
Acta Physiol Scand Suppl. 1967;300:1-71.
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Stimulation of polyamine synthesis in relation to nucleic acids in regenerating rat liver.再生大鼠肝脏中多胺合成与核酸的关系研究
Biochim Biophys Acta. 1966 Jul 20;123(1):197-201. doi: 10.1016/0005-2787(66)90173-0.
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Changes in polyamine content of rat liver following hypophysectomy and treatment with growth hormone.垂体切除及生长激素治疗后大鼠肝脏中多胺含量的变化
Biochem Biophys Res Commun. 1966 Apr 19;23(2):150-5. doi: 10.1016/0006-291x(66)90520-1.
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Hormonal effects on spermidine levels in male and female reproductive organs of the rat.激素对大鼠雄性和雌性生殖器官中精胺水平的影响。
Endocrinology. 1969 Jun;84(6):1461-5. doi: 10.1210/endo-84-6-1461.
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Effect of polyamines on ribosomal RNA synthesis during sea urchin development.多胺对海胆发育过程中核糖体RNA合成的影响。
Exp Cell Res. 1968 Jun;50(3):671-4. doi: 10.1016/0014-4827(68)90434-5.
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