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1
In vitro effect of virazole against influenza viruses.病毒唑对流感病毒的体外作用
Antimicrob Agents Chemother. 1973 Dec;4(6):641-2. doi: 10.1128/AAC.4.6.641.
2
An evaluation of a new antiviral agent "virazole" against influenza virus infections.
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3
In vitro effect of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (virazole, ICN 1229) on deoxyribonucleic acid and ribonucleic acid viruses.1-β-D-呋喃核糖基-1,2,4-三唑-3-甲酰胺（病毒唑，ICN 1229）对脱氧核糖核酸病毒和核糖核酸病毒的体外作用
Antimicrob Agents Chemother. 1973 Feb;3(2):235-41. doi: 10.1128/AAC.3.2.235.
4
Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide.病毒唑的广谱抗病毒活性：1-β-D-呋喃核糖基-1,2,4-三唑-3-甲酰胺。
Science. 1972 Aug 25;177(4050):705-6. doi: 10.1126/science.177.4050.705.
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Mechanism of action of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole), a new broad-spectrum antiviral agent.新型广谱抗病毒药物1-β-D-呋喃核糖基-1,2,4-三唑-3-甲酰胺（病毒唑）的作用机制
Proc Natl Acad Sci U S A. 1973 Apr;70(4):1174-8. doi: 10.1073/pnas.70.4.1174.
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[Antiinfluenza virus activity of virazole by means of quantitative hemadsorption technique (author's transl)].用定量血细胞吸附技术测定病毒唑的抗流感病毒活性（作者译）
Uirusu. 1974 Aug;24(2):175-80. doi: 10.2222/jsv.24.175.
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In vitro and in vivo activities of anti-influenza virus compound T-705.抗流感病毒化合物T-705的体外和体内活性
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[Effect of virazole on the antiviral activity of poly(G) X poly(C) and other polyribonucleotide interferonogens].
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引用本文的文献

1
Plaque inhibition assay for drug susceptibility testing of influenza viruses.用于流感病毒药物敏感性测试的噬斑抑制试验。
Antimicrob Agents Chemother. 1980 May;17(5):865-70. doi: 10.1128/AAC.17.5.865.
2
Comparative activity of amantadine and ribavirin against influenza virus in vitro: possible clinical relevance.金刚烷胺与利巴韦林对流感病毒的体外比较活性：可能的临床意义。
Antimicrob Agents Chemother. 1983 Mar;23(3):503-5. doi: 10.1128/AAC.23.3.503.
3
Comparative inhibition of influenza and parainfluenza virus replication by ribavirin in MDCK cells.利巴韦林对MDCK细胞中流感病毒和副流感病毒复制的抑制作用比较
Antimicrob Agents Chemother. 1981 May;19(5):712-5. doi: 10.1128/AAC.19.5.712.
4
Ribavirin and inosiplex: a review of their present status in viral diseases.利巴韦林与肌苷：它们在病毒性疾病中的现状综述
Drugs. 1981 Aug;22(2):111-28. doi: 10.2165/00003495-198122020-00002.
5
Ribavirin: a clinical overview.利巴韦林：临床概述。
Eur J Epidemiol. 1986 Mar;2(1):1-14. doi: 10.1007/BF00152711.
6
Efficacy of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide against influenza virus infections in mice.1-β-D-呋喃核糖基-1,2,4-三唑-3-甲酰胺对小鼠流感病毒感染的疗效。
Antimicrob Agents Chemother. 1975 May;7(5):582-6. doi: 10.1128/AAC.7.5.582.
7
Effects of small-particle aerosols of rimantadine and ribavirin on arterial blood pH and gas tensions and lung water content of A2 influenza-infected mice.金刚烷胺和利巴韦林小颗粒气溶胶对感染A2型流感小鼠动脉血pH值、气体张力及肺含水量的影响。
Antimicrob Agents Chemother. 1977 Jul;12(1):40-6. doi: 10.1128/AAC.12.1.40.

本文引用的文献

1
Antiviral activity of cyclooctylamine hydrochloride in cell culture and mouse systems.
Antimicrob Agents Chemother (Bethesda). 1968;8:194-200. doi: 10.1128/AAC.8.2.194.
2
Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide.病毒唑的广谱抗病毒活性：1-β-D-呋喃核糖基-1,2,4-三唑-3-甲酰胺。
Science. 1972 Aug 25;177(4050):705-6. doi: 10.1126/science.177.4050.705.
3
Inhibition of influenza viruses in vitro and in vivo by 1-adamantanamine hydrochloride.盐酸金刚烷胺在体外和体内对流感病毒的抑制作用。
Br J Exp Pathol. 1965 Jun;46(3):263-73.
4
In vitro effect of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (virazole, ICN 1229) on deoxyribonucleic acid and ribonucleic acid viruses.1-β-D-呋喃核糖基-1,2,4-三唑-3-甲酰胺（病毒唑，ICN 1229）对脱氧核糖核酸病毒和核糖核酸病毒的体外作用
Antimicrob Agents Chemother. 1973 Feb;3(2):235-41. doi: 10.1128/AAC.3.2.235.

病毒唑对流感病毒的体外作用

In vitro effect of virazole against influenza viruses.

作者信息

Togo Y

出版信息

Antimicrob Agents Chemother. 1973 Dec;4(6):641-2. doi: 10.1128/AAC.4.6.641.

DOI:10.1128/AAC.4.6.641
PMID:4793883
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC444610/
Abstract

The minimal inhibitory concentrations of Virazole against 32 mean tissue culture infective doses of three type A influenza strains including type A/England/42/72 (H3N2) and a type B strain in tissue culture were 0.1 and 0.05 mug/ml, respectively. The growth inhibition pattern by various Virazole concentrations of type A virus was similar to that of the type B virus. Virazole appears to be slightly more potent against the A/England/42/72 strain than are other antiinfluenzal agents.

摘要

病毒唑在组织培养中对包括A/英格兰/42/72（H3N2）在内的三种甲型流感病毒株以及一种乙型流感病毒株的32个平均组织培养感染剂量的最低抑菌浓度分别为0.1和0.05微克/毫升。不同浓度病毒唑对甲型病毒的生长抑制模式与乙型病毒相似。病毒唑对A/英格兰/42/72株的效力似乎略高于其他抗流感药物。