妊娠血清对实验性炎症的影响。
Effect of pregnancy serum on experimental inflammation.
作者信息
Persellin R H, Vance S E, Peery A
出版信息
Br J Exp Pathol. 1974 Feb;55(1):26-32.
Experimental inflammation induced in the rat by injection of carrageenin was suppressed by prior administration of pooled serum obtained from pregnant human females. Inflammatory oedema in the rat hind paw measured by a plethysmograph was inhibited 81% by 10 ml of pregnancy serum pool and the effect was dose related. Non-pregnant female serum was inhibitory to a lesser degree and no anti-inflammatory action was detected using cord serum. Although adrenal corticosteroid hormones could modify this inflammatory model, their presence in the serum pools could not account for the effects observed. Since carrageenin is sequestered within phagolysosomes and provokes release of their inflammation-inducing contents, it is suggested that the protective effect of pregnancy serum on carrageenin inflammation is mediated lysosomal stabilization.
通过注射角叉菜胶在大鼠体内诱导的实验性炎症，可被预先给予的来自怀孕女性的混合血清所抑制。用体积描记器测量的大鼠后爪炎性水肿，10毫升怀孕血清混合物可抑制81%，且该效应与剂量相关。未怀孕女性血清的抑制作用较小，使用脐带血清未检测到抗炎作用。虽然肾上腺皮质类固醇激素可改变这种炎症模型，但血清混合物中它们的存在无法解释所观察到的效应。由于角叉菜胶被隔离在吞噬溶酶体内并引发其炎症诱导性内容物的释放，因此提示怀孕血清对角叉菜胶炎症的保护作用是通过溶酶体稳定介导的。
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