Gulmann N C, Hammerberg P E, Jensen L B, Sommerbeck K W, Orbaek K
Acta Neurol Scand. 1979 Jun;59(6):324-30. doi: 10.1111/j.1600-0404.1979.tb02943.x.
Cerebral asthenopia is often overlooked as a symptom in diffuse brain lesion. An objective correlate of this symptom has so far never been demonstrated. Averaged visual evoked potential (VEP) in 10 patients with asthenopia was compared with 20 normal subjects. Both eyes and each eye alone were stimulated using bipolar recording in the midline and over each of the occipital lobes. There was no difference of latency of the VEPs in the two groups, but the amplitude of the most prominent component was significantly reduced in the patients. There was also a difference in the two groups regarding habituation and lateralisation. No amplitude difference could be found in the somatosensory evoked potential. The amplitude difference in VEP, as an objective correlate of asthenopia, is probably modal specific and suggests involvement of the visual cortex. VEP is unsuitable as a diagnostic tool due to the great overlap between amplitudes in asthenopic patients and control subjects.
脑性视疲劳作为弥漫性脑损伤的一种症状常常被忽视。迄今为止，这一症状尚未找到客观相关指标。对10例视疲劳患者的平均视觉诱发电位（VEP）与20名正常受试者进行了比较。使用双极记录法在中线及每个枕叶上方分别刺激双眼及单眼。两组VEP的潜伏期无差异，但患者组中最显著成分的波幅明显降低。两组在习惯化和偏侧化方面也存在差异。体感诱发电位未发现波幅差异。VEP中的波幅差异作为视疲劳的客观相关指标，可能具有模式特异性，提示视觉皮层受累。由于视疲劳患者与对照组的波幅存在很大重叠，VEP不适合作为诊断工具。
