抗体及抗原-抗体复合物与脾淋巴细胞上受体的竞争性结合。
Competitive binding of antibodies and antigen-antibody complexes to receptors on spleen lymphocytes.
作者信息
Niederer W
出版信息
Immunology. 1974 Jan;26(1):137-43.
Abstract
We have confirmed that adherence of antibodies to spleen lymphocytes is stabilized when the antibodies form complexes with antigen. Furthermore, there is evidence that antibodies having both binding sites occupied are less easily supplanted from the lymphocyte receptor by unspecific IgG than antibodies carrying one antigen only. Based on these results a hypothetical model for a feed-back control of the humoral immune response is put forward.
摘要
我们已经证实，当抗体与抗原形成复合物时，其与脾淋巴细胞的黏附会得到稳定。此外，有证据表明，与仅携带一种抗原的抗体相比，两个结合位点都被占据的抗体更不容易被非特异性IgG从淋巴细胞受体上取代。基于这些结果，我们提出了一个体液免疫反应反馈控制的假设模型。
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Enzymatic iodination of polypeptides with 125I to high specific activity.用¹²⁵I对多肽进行酶促碘化以获得高比活度。
Biochim Biophys Acta. 1971 Dec 28;251(3):363-9. doi: 10.1016/0005-2795(71)90123-1.
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The preparation and properties of purified 125-I-labelled antibodies to insulin.纯化的125-I标记胰岛素抗体的制备及其性质
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Cell surface immunoglobulin. IV. Distribution among thymocytes, bone mrrow cells, and their derived populations.细胞表面免疫球蛋白。IV. 在胸腺细胞、骨髓细胞及其衍生群体中的分布。
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A receptor for antibody on B lymphocytes. II. Immunochemical and electron microscopy characteristics.B淋巴细胞上的抗体受体。II. 免疫化学和电子显微镜特征
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