麻醉对阿托品诱导的大鼠五肽胃泌素诱发胃酸分泌抑制作用的影响。
The effect of anaesthesia on the inhibition of pentagastrin-evoked gastric acid secretion induced by atropine in the rat.
作者信息
Hedges A R, Parsons M E
出版信息
J Physiol. 1977 May;267(1):181-94. doi: 10.1113/jphysiol.1977.sp011807.
Abstract
- In the anaesthetized, vagally intact rat, with a perfused gastric lumen, atropine produced a maximum inhibition of 60% of maximal pentagastrin-evoked gastric acid secretion. Sub-maximal pentagastrin-stimulated secretion was also inhibited by atropine.2. In the anaesthetized, vagotomized rat, with a perfused gastric lumen, atropine had no inhibitory effect on maximal pentagastrin-evoked gastric acid secretion.3. In the conscious fistula rat, atropine totally abolished both the basal gastric acid secretion and the maximal gastric acid secretion evoked by pentagastrin. In the anaesthetized chronic fistula rat, doses of atropine up to 1.6 mg.kg(-1) administered subcutaneously produced a maximum inhibition of 70% of maximal pentagastrin-evoked gastric acid secretion. Vagotomy did not affect the response to atropine.4. In the conscious Heidenhain pouch rat, doses of atropine up to 1.6 mg.kg(-1) administered subcutaneously produced a maximum inhibition of 70.9% of maximal pentagastrin-evoked gastric acid secretion. Both anaesthesia and vagotomy, alone or in combination, did not affect the response to atropine.
摘要
在麻醉状态下、迷走神经完整且胃腔灌注的大鼠中，阿托品对五肽胃泌素诱发的最大胃酸分泌产生了60%的最大抑制作用。次最大剂量五肽胃泌素刺激的分泌也受到阿托品的抑制。
在麻醉状态下、迷走神经切断且胃腔灌注的大鼠中，阿托品对五肽胃泌素诱发的最大胃酸分泌没有抑制作用。
在清醒的瘘管大鼠中，阿托品完全消除了基础胃酸分泌以及五肽胃泌素诱发的最大胃酸分泌。在麻醉的慢性瘘管大鼠中，皮下注射高达1.6mg·kg⁻¹的阿托品剂量对五肽胃泌素诱发的最大胃酸分泌产生了70%的最大抑制作用。迷走神经切断术不影响对阿托品的反应。
在清醒的海登海因小胃大鼠中，皮下注射高达1.6mg·kg⁻¹的阿托品剂量对五肽胃泌素诱发的最大胃酸分泌产生了70.9%的最大抑制作用。单独或联合使用麻醉和迷走神经切断术均不影响对阿托品的反应。
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