通过合成牛血清白蛋白的五个抗原位点进行定位与验证。
Localization and verification by synthesis of five antigenic sites of bovine serum albumin.
作者信息
Atassi M Z, Sakata S, Kazim A L
出版信息
Biochem J. 1979 May 1;179(2):327-31. doi: 10.1042/bj1790327.
Abstract
Recently we have shown that the major antigenic sites of bovine serum albumin exhibit functional equivalence progessively increasing with the time at which antibodies are obtained after the first immunization. Analysis of our recent immunochemical findings and the known covalent structure of bovine serum albumin have enabled us to predict the locations of five antigenic sites of bovine serum albumin. The predicted locations were synthesized, and immunochemical studies with late-course antisera showed them to constitute antigenic sites of native bovine serum albumin.
摘要
最近我们发现，牛血清白蛋白的主要抗原位点呈现出功能等效性，且随着首次免疫后获得抗体的时间推移而逐渐增强。对我们最近的免疫化学研究结果以及已知的牛血清白蛋白共价结构进行分析后，我们得以预测牛血清白蛋白五个抗原位点的位置。我们合成了预测的位点，并用后期抗血清进行免疫化学研究，结果表明它们构成了天然牛血清白蛋白的抗原位点。
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本文引用的文献
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