钾离子扩散电位导致嗜铬颗粒“空壳”摄取肾上腺素。
A potassium ion diffusion potential causes adrenaline uptake in chromaffin-granule 'ghosts'.
作者信息
Njus D, Radda G K
出版信息
Biochem J. 1979 Jun 15;180(3):579-85. doi: 10.1042/bj1800579.
Abstract
Membrane vesicles ('ghosts') formed from bovine chromaffin granules accumulate adrenaline in response to a diffusion potential produced by adding K+ in the presence of valinomycin. This uptake occurs as a short (2--5 min) burst because of the transient nature of the diffusion potential. The potential-driven uptake is optimal at pH approximately 7.2, is inhibited by reserpine, and has an initial rate comparable with that of ATP-driven uptake. These results show that ATP-dependent adrenaline uptake may occur at least partly in response to the membrane potential generated by an electrogenic proton-translocating adenosine triphosphatase found in chromaffin-granule membranes.
摘要
由牛嗜铬颗粒形成的膜泡（“空泡”）在缬氨霉素存在下添加钾产生的扩散电位作用下积累肾上腺素。由于扩散电位的短暂性，这种摄取以短时间（2 - 5分钟）的爆发形式发生。电位驱动的摄取在pH约为7.2时最佳，受利血平抑制，其初始速率与ATP驱动的摄取相当。这些结果表明，依赖ATP的肾上腺素摄取可能至少部分是对嗜铬颗粒膜中发现的一种生电质子转运三磷酸腺苷酶产生的膜电位作出的反应。
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