Aarli J A
Clin Exp Immunol. 1970 Jul;7(1):23-30.
Serum γ-globulins from normal persons and from twenty-four patients with myasthenia gravis were tested in the antiglobulin consumption test before and after pepsin digestion. F(ab') fragments prepared from normal sera did not bind to muscle tissue, while Fc fragments did. Accordingly, muscle binding γ-globulins from normal sera bind to the tissue only by the Fc portion of the molecule. F(ab') preparations from sera from patients with myasthenia gravis combined with the tissue. In twelve of these sera, the amount of muscle binding γ-globulin was shown to be quantitatively within normal limits. The difference in binding capacity registered between the different patient sera is quantitative, while the data indicate a qualitative difference between normal and patient sera.
对正常人以及24例重症肌无力患者的血清γ球蛋白进行了胃蛋白酶消化前后的抗球蛋白消耗试验。从正常血清制备的F(ab')片段不与肌肉组织结合，而Fc片段则与之结合。因此，正常血清中与肌肉结合的γ球蛋白仅通过分子的Fc部分与组织结合。重症肌无力患者血清的F(ab')制剂与组织结合。在其中12份血清中，与肌肉结合的γ球蛋白量经测定在正常范围内。不同患者血清之间记录到的结合能力差异是定量的，而数据表明正常血清与患者血清之间存在质的差异。
