Seargeant L E, Stinson R A
Biochem J. 1979 Jul 1;181(1):247-50. doi: 10.1042/bj1810247.
Orthovanadate was shown to be a potent competitive inhibitor (Ki less than 1 microM) of purified alkaline phosphatase from human liver, intestine of kidney. Inhibition was reversed and full enzymic activity restored in the presence of 1mM-adrenaline. Phosphate and vanadate competed for the same binding site on the enzyme.
原钒酸盐被证明是一种有效的竞争性抑制剂（抑制常数Ki小于1微摩尔），可抑制从人肝脏、肾脏和肠道中纯化得到的碱性磷酸酶。在1毫摩尔肾上腺素存在的情况下，抑制作用被逆转，酶的全部活性得以恢复。磷酸盐和钒酸盐在酶上竞争同一个结合位点。
