大肠杆菌的异亮氨酸和缬氨酸代谢。十四。硫代异亮氨酸的作用。
Isoleucine and valine metabolism of Escherichia coli. XIV. Effect of thiaisoleucine.
作者信息
Szentirmai A, Umbarger H E
出版信息
J Bacteriol. 1968 May;95(5):1666-71. doi: 10.1128/jb.95.5.1666-1671.1968.
Abstract
Thiaisoleucine (2-amino-3-methylthiobutyrate) completely inhibited the growth of strain K-12 of Escherichia coli at a concentration of 5 x 10(-3)m. The inhibition was antagonized by growth-factor amounts of l-isoleucine. Thiaisoleucine inhibited the deamination of threonine and the transfer of (14)C-isoleucine to soluble ribonucleic acid and underwent transamination with alpha-ketoglutarate as the amino acceptor. In each case, the analogue appeared to be less effective than isoleucine as either an inhibitor or substrate.
摘要
硫代异亮氨酸（2-氨基-3-甲基硫代丁酸）在浓度为5×10⁻³m时完全抑制大肠杆菌K-12菌株的生长。这种抑制作用可被生长因子量的L-异亮氨酸所拮抗。硫代异亮氨酸抑制苏氨酸的脱氨基作用以及（¹⁴C）-异亮氨酸向可溶性核糖核酸的转移，并以α-酮戊二酸作为氨基受体进行转氨基作用。在每种情况下，该类似物作为抑制剂或底物似乎都比异亮氨酸效果差。
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