β-氯丙氨酸对鼠伤寒沙门氏菌生长以及苏氨酸脱氨酶和转氨酶B的抑制作用。
Inhibition of growth of Salmonella typhimurium and of threonine deaminase and transaminase B by beta-chloroalanine.
作者信息
Arfin S M, Koziell D A
出版信息
J Bacteriol. 1971 Feb;105(2):519-22. doi: 10.1128/jb.105.2.519-522.1971.
Abstract
beta-Chloro-l-alanine (CA) was found to inhibit the growth of Salmonella typhimurium. The inhibition was overcome by isoleucine plus valine. CA inhibited the activity of threonine deaminase and transaminase B in vitro. The inhibition of threonine deaminase was reversible and was not affected by desensitization to isoleucine inhibition. Transaminase B was irreversibly inactivated. Derepression of some of the isoleucine and valine biosynthetic enzymes was achieved by growth of wild-type cells on low levels of CA.
摘要
β-氯-L-丙氨酸（CA）被发现可抑制鼠伤寒沙门氏菌的生长。异亮氨酸加缬氨酸可克服这种抑制作用。CA在体外抑制苏氨酸脱氨酶和转氨酶B的活性。苏氨酸脱氨酶的抑制作用是可逆的，且不受对异亮氨酸抑制脱敏的影响。转氨酶B被不可逆地灭活。通过野生型细胞在低水平CA上生长，实现了一些异亮氨酸和缬氨酸生物合成酶的去阻遏。
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