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J Exp Med. 1968 Jul 1;128(1):111-9. doi: 10.1084/jem.128.1.111.
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Studies on the mode of action of heterologous anti-lymphocyte plasma. II. The effect of anti-lymphocyte plasma on lymphocyte counts.异种抗淋巴细胞血浆作用方式的研究。II. 抗淋巴细胞血浆对淋巴细胞计数的影响。
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An automatic optical method for detection of rat lymphocyte subpopulations.一种检测大鼠淋巴细胞亚群的自动光学方法。
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An in vitro reaction between labelled flagellin or haemocyanin and lymphocyte-like cells from normal animals.标记鞭毛蛋白或血蓝蛋白与正常动物淋巴细胞样细胞之间的体外反应。
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引用本文的文献

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Effects of heterologous antineutrophil serum in guinea pigs. Hematologic and ultrastructural observations.异源抗中性粒细胞血清对豚鼠的影响。血液学和超微结构观察。
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Anti-thymocyte serum effects on Plasmodium berghei infection in rats.抗胸腺细胞血清对大鼠伯氏疟原虫感染的影响。
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The selective action of antilymphocyte serum on recirculating lymphocytes: a review of the evidence and alternatives.抗淋巴细胞血清对再循环淋巴细胞的选择性作用：证据与替代方法综述
Clin Exp Immunol. 1970 Jun;6(6):789-802.

本文引用的文献

1
EFFECT OF LYMPHOCYTE DEPLETION BY THORACIC DUCT FISTULA AND ADMINISTRATION OF ANTILYMPHOCYTIC SERUM ON THE SURVIVAL OF SKIN HOMOGRAFTS IN RATS.胸导管瘘致淋巴细胞耗竭及给予抗淋巴细胞血清对大鼠皮肤同种移植存活的影响
Nature. 1963 Nov 16;200:702. doi: 10.1038/200702a0.
2
The use of specific "lymphocyte" antisera to inhibit hypersensitive reactions of the "delayed" type.使用特异性“淋巴细胞”抗血清抑制“迟发型”超敏反应。
J Exp Med. 1961 Dec 1;114(6):997-1022. doi: 10.1084/jem.114.6.997.
3
The fate of parental strain small lymphocytes in F1 hybrid rats.亲本品系小淋巴细胞在F1杂种大鼠中的命运。
Ann N Y Acad Sci. 1962 Oct 24;99:432-55. doi: 10.1111/j.1749-6632.1962.tb45326.x.
4
Quantitative studies on the induction of tolerance of skin homografts and on runt disease in neonatal rats.新生大鼠皮肤同种异体移植耐受性诱导及矮小病的定量研究。
J Natl Cancer Inst. 1962 Feb;28:365-435.
5
Nature and mode of action of antilymphocytic antiserum.抗淋巴细胞抗血清的性质与作用方式。
Proc Natl Acad Sci U S A. 1966 Oct;56(4):1130-7. doi: 10.1073/pnas.56.4.1130.
6
Studies on heterologous anti-lymphocyte serum in mice. II. Effect on the immune response.小鼠异种抗淋巴细胞血清的研究。II. 对免疫反应的影响。
J Immunol. 1966 Feb;96(2):229-38.
7
The relationship of lymphopenia production and lymphocyte agglutinating and cytotoxic antibody titers to the immunosuppressive potency of heterologous antilymphocyte plasma.淋巴细胞减少的产生、淋巴细胞凝集抗体和细胞毒性抗体效价与异种抗淋巴细胞血浆免疫抑制效力的关系。
Transplantation. 1967 Jul;5(4):Suppl:1121-6.
8
Studies on heterologous anti-lymphocyte serum in mice. I. In vitro and in vivo properties.小鼠异种抗淋巴细胞血清的研究。I. 体外和体内特性。
J Immunol. 1966 Feb;96(2):217-28.
9
Immunological reactivity of lymphoid cells after treatment with anti-lymphocytic serum.抗淋巴细胞血清处理后淋巴细胞的免疫反应性
Nature. 1967 Sep 30;215(5109):1461-4. doi: 10.1038/2151461a0.
10
Further experiments on the action of antilymphocytic antiserum.抗淋巴细胞抗血清作用的进一步实验。
Proc Natl Acad Sci U S A. 1967 Aug;58(2):470-7. doi: 10.1073/pnas.58.2.470.

异种抗淋巴细胞血清对大鼠小淋巴细胞群体的影响。

The effect of heterologous anti-lymphocytic serum on the small lymphocyte population of rats.

作者信息

Agnew H D

出版信息

J Exp Med. 1968 Jul 1;128(1):111-9. doi: 10.1084/jem.128.1.111.

DOI:10.1084/jem.128.1.111
PMID:4873839
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2138510/
Abstract

Treatment of Lewis strain rats with a single subcutaneous dose of rabbit anti-rat thymocyte serum (RARTS) resulted in a marked depletion of small lymphocytes in the blood and thoracic duct lymph for approximately 10 days. While the thoracic duct lymphocytes were declining in numbers, rabbit antibody could be detected on the surfaces of a high percentage of the lymph cells. Furthermore, the thoracic duct lymphocytes were unable to initiate graft vs. host reactions during the period of depletion, even when injected in extremely large doses. Approximately 2 wk after treatment, the numbers and immune competence of the small lymphocytes returned to normal.

摘要

用单剂量兔抗大鼠胸腺细胞血清（RARTS）皮下注射处理Lewis品系大鼠，可使血液和胸导管淋巴中的小淋巴细胞显著减少约10天。当胸导管淋巴细胞数量下降时，可在高比例的淋巴细胞表面检测到兔抗体。此外，在淋巴细胞减少期间，胸导管淋巴细胞即使注射极大剂量也无法引发移植物抗宿主反应。治疗后约2周，小淋巴细胞的数量和免疫能力恢复正常。