异种抗淋巴细胞血清对大鼠小淋巴细胞群体的影响。
The effect of heterologous anti-lymphocytic serum on the small lymphocyte population of rats.
作者信息
Agnew H D
出版信息
J Exp Med. 1968 Jul 1;128(1):111-9. doi: 10.1084/jem.128.1.111.
Abstract
Treatment of Lewis strain rats with a single subcutaneous dose of rabbit anti-rat thymocyte serum (RARTS) resulted in a marked depletion of small lymphocytes in the blood and thoracic duct lymph for approximately 10 days. While the thoracic duct lymphocytes were declining in numbers, rabbit antibody could be detected on the surfaces of a high percentage of the lymph cells. Furthermore, the thoracic duct lymphocytes were unable to initiate graft vs. host reactions during the period of depletion, even when injected in extremely large doses. Approximately 2 wk after treatment, the numbers and immune competence of the small lymphocytes returned to normal.
摘要
用单剂量兔抗大鼠胸腺细胞血清（RARTS）皮下注射处理Lewis品系大鼠，可使血液和胸导管淋巴中的小淋巴细胞显著减少约10天。当胸导管淋巴细胞数量下降时，可在高比例的淋巴细胞表面检测到兔抗体。此外，在淋巴细胞减少期间，胸导管淋巴细胞即使注射极大剂量也无法引发移植物抗宿主反应。治疗后约2周，小淋巴细胞的数量和免疫能力恢复正常。
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