Kennedy A L, Kandell T W, Merimee T J
Diabetes. 1979 Nov;28(11):1006-10. doi: 10.2337/diab.28.11.1006.
To determine whether the carbohydrate content of serum proteins is related to overall glycemic control, we studied serum protein-bound hexose and glycosylated hemoglobin [HbA1(a+b+c)] in 37 ambulant diabetic patients and 32 nondiabetic controls. Protein-bound hexose was correlated with HbA1(a+b+c) in the diabetic patients (r = 0.36, P less than 0.025). The mean protein-bound hexose level of the diabetic patients was greater than that of the controls (190.8 versus 174.7 mg/dl, P less than 0.01), but diabetic patients with HbA1(a+b+c) less than 12% had a mean protein-bound hexose similar to the controls. In nine of the diabetic patients, mean protein-bound hexose and HbA1(a+b+c) were significantly reduced during a period of intensive outpatient care, while two major serum glycoproteins, haptoglobins and alpha-1-antitrypsin, were unchanged. Our findings support the hypothesis that increased glycosylation of serum proteins may occur in diabetes mellitus; this abnormality in serum protein-bound hexose may be corrected by close attention to overall glycemic control.
为了确定血清蛋白的碳水化合物含量是否与整体血糖控制有关，我们研究了37例非卧床糖尿病患者和32例非糖尿病对照者的血清蛋白结合己糖和糖化血红蛋白[HbA1(a+b+c)]。糖尿病患者的蛋白结合己糖与HbA1(a+b+c)相关(r = 0.36，P<0.025)。糖尿病患者的平均蛋白结合己糖水平高于对照组(190.8对174.7mg/dl，P<0.01)，但HbA1(a+b+c)低于12%的糖尿病患者的平均蛋白结合己糖与对照组相似。在9例糖尿病患者中，强化门诊治疗期间平均蛋白结合己糖和HbA1(a+b+c)显著降低，而两种主要血清糖蛋白，即触珠蛋白和α1-抗胰蛋白酶，未发生变化。我们的研究结果支持以下假设：糖尿病患者可能会出现血清蛋白糖基化增加；通过密切关注整体血糖控制，血清蛋白结合己糖的这种异常情况可能会得到纠正。
