Cimetidine and salbutamol combined inhibition of gastric acid secretion in the dog.

The effects of salbutamol and cimetidine, alone and in combination, on pentagastrin-stimulated gastric secretion have been studied in conscious dogs with gastric fistulae. Salbutamol 24 nmol/kg.h alone and cimetidine 4 mumol/kg.h alone inhibited acid up to 69%, cimetidine 8 mumol/kg.h produced up to 87% inhibition and the combination of cimetidine 4 mumol/kg.h and salbutamol 24 nmol/kg.h almost totally inhibited acid (up to 99%). The pharmacokinetics of these inhibitions were studied and salbutamol and/or cimetidine caused a complex uncompetitive inhibition of pentagastrin-stimulated acid. The inhibitory combination of the two drugs was additive.