Gastric acid secretion after chronic administration of the anti-secretory agent salbutamol in the dog.

Salbutamol is known to be a potent inhibitor of pentagastrin stimulated gastric acid secretion in both man and dog. This study describes the results, in both acute and chronic experiments in the dog, of salbutamol administration on gastric acid output and plasma gastrin concentration in response to a standard food stimulus. In the acute experiments, salbutamol in fusion reduced both gastric acid output and peak plasma gastrin concentration. In contrast, during chronic oral administration, salbutanmol caused a significant increase in the acid secretory response to the food stimulus; 2 weeks after the drug was stopped acid output has returned to control values. Only small changes in plasma gastrin concentration were found in the chronic study and these changes could not explain the increase in acid output.