Suzuki O, Ishii K, Nagata H, Miyairi M, Mizuno Y, Kiryu Y, Tsuchiya M
Gastroenterol Jpn. 1979 Aug;14(4):336-43. doi: 10.1007/BF02774230.
Plasma histamine level (PHL) was evaluated by a modified fluorometric assay (Suzuki) in the patients with various forms of liver disease as well as rabbits with liver injury. And the data obtained were compared with liver function tests in assessing the stage and prognosis of hepatic dysfunction. In acute hepatitis, if its prognosis was "good", as was also shown in the animal group with single dose administration of CCl4, the level of plasma histamine attained a peak before that of serum transaminases, and returned to normal prior to that of the latter. In persistent and chronic hepatitis, although correlation between PHL and other liver function tests was poor and variable, PHL remained high. And the estimation of PHL during the course of this state showed that it was elevated prior to that of serum transaminases, in dicating high level of plasma histamine in this state, even in apparent "steady state", worsening of the disease. In liver cirrhosis PHL correlated with the degree of serum transaminases as well as serum gammaglobulin. In "poor prognosis" group (patients with hepatic coma and rabbits treated with consecutive administration of CCl4) PHL increased extremely high, which was contrasted with the lowered levels of transaminases. These results strikingly suggest that histamine is involved in liver injury and estimation of PHL in the course of hepatic disorder is useful for a prediction of prognosis.
采用改良荧光测定法（铃木法）评估各种肝病患者以及肝损伤兔的血浆组胺水平（PHL）。将获得的数据与肝功能检查结果进行比较，以评估肝功能障碍的阶段和预后。在急性肝炎中，如果其预后“良好”（单次给予四氯化碳的动物组也显示如此），血浆组胺水平在血清转氨酶之前达到峰值，并在后者之前恢复正常。在持续性和慢性肝炎中，虽然PHL与其他肝功能检查之间的相关性较差且不稳定，但PHL仍保持较高水平。在此状态过程中对PHL的评估表明，它在血清转氨酶升高之前就已升高，这表明即使在明显的“稳定状态”下，该状态下血浆组胺水平也较高，病情仍在恶化。在肝硬化中，PHL与血清转氨酶水平以及血清γ球蛋白相关。在“预后不良”组（肝昏迷患者和连续给予四氯化碳治疗的兔）中，PHL极度升高，这与转氨酶水平降低形成对比。这些结果显著表明，组胺参与肝损伤，在肝病过程中评估PHL有助于预测预后。
