Glynn A A
Immunology. 1969 Apr;16(4):463-71.
Suspensions of were not affected by lysozyme alone, but in solutions of appropriate pH and ionic strength some lysozyme was bound to the bacterial surface and remained available for action if the bacteria were subsequently treated with antibody and complement. In the presence of antibody, complement had a relatively prolonged action on ending in lysis. However, from an early stage in the reaction this lysis could be accelerated by adding lysozyme. The results suggest that human complement acted on the outer, lipoprotein—lipopolysaccharide layers of the bacterial cell wall and so gave lysozyme access to the deeper mucopeptide. When the number of bound lysozyme molecules per bacterium was less than 10,000–20,000 the lysozyme effect decreased rapidly. However, many of these molecules may have been inactivated by K antigen.
单独的溶菌酶对[细菌名称]悬浮液没有影响，但在适当pH和离子强度的溶液中，一些溶菌酶会结合到细菌表面，如果随后用抗体和补体处理细菌，这些溶菌酶仍可发挥作用。在有抗体存在的情况下，补体对[细菌名称]有相对持久的作用，最终导致裂解。然而，从反应的早期阶段开始，加入溶菌酶可加速这种裂解。结果表明，人补体作用于细菌细胞壁的外层脂蛋白-脂多糖层，从而使溶菌酶能够接触到更深层的粘肽。当每个细菌结合的溶菌酶分子数少于10000-20000时，溶菌酶的作用迅速降低。然而，这些分子中的许多可能已被K抗原灭活。
