Bellavia A, Ure J, Ammatuna P, Caruso C, Salerno A
Int Arch Allergy Appl Immunol. 1979;60(3):249-57. doi: 10.1159/000232349.
The effect of Newcastle disease virus (NDV) on delayed hypersensitivity to oxazolone in CBA mice was studied. There was a significant impairment of the ability of mice to develop cutaneous hypersensitivity shortly after injection of the virus. The effect was evident when NDV was administered up to 2 days before or within 24 h after sensitization, suggesting that NDV interferes with the process of sensitization. The degree of depression was related to the dose of virus inoculated. NDV inactivated by UV irradiation or heat did not depress contact sensitivity to oxazolone. These data are considered to support the hypothesis that the depression is mediated by a direct interaction between lymphocytes and NDV.
研究了新城疫病毒（NDV）对CBA小鼠迟发型对恶唑酮超敏反应的影响。在注射病毒后不久，小鼠产生皮肤超敏反应的能力出现显著受损。当在致敏前2天内或致敏后24小时内给予NDV时，这种影响很明显，这表明NDV干扰了致敏过程。抑制程度与接种病毒的剂量有关。经紫外线照射或加热灭活的NDV不会降低对恶唑酮的接触敏感性。这些数据被认为支持这样的假设，即这种抑制是由淋巴细胞与NDV之间的直接相互作用介导的。
