Caruso C, Bellavia A, Cillari E, Ascoli R, Pavone-Macaluso M
Tumori. 1977 Mar-Apr;63(2):147-54. doi: 10.1177/030089167706300204.
A study has been carried out on the immunosuppressive activity of high doses of peptichemio (PTC) in CBA mice. Humoral response to sheep erythrocytes, delayed hypersensitivity to oxazolone, and cellular proliferation in lymph nodes and spleen of animals sensitized with oxazolone have been investigated. The results demonstrated that PTC had a definite immunosuppressive action, as shown by the inhibition of primary response to inoculation of sheep erythrocytes, by depression of delayed hypersensitivity to oxazolone, and by marked inhibition of 125IUdr incorporation in lymph nodes of sensitized animals. It is suggested that the inhibitory action is mediated by an effect on actively proliferating B or T lymphoid cells, although involvement of macrophages cannot be ruled out.
对高剂量的胃酶抑素（PTC）在CBA小鼠中的免疫抑制活性进行了一项研究。研究了动物对绵羊红细胞的体液反应、对恶唑酮的迟发型超敏反应以及用恶唑酮致敏的动物淋巴结和脾脏中的细胞增殖情况。结果表明，PTC具有明确的免疫抑制作用，表现为对接种绵羊红细胞的初次反应的抑制、对恶唑酮迟发型超敏反应的降低以及对致敏动物淋巴结中125IUdr掺入的显著抑制。提示这种抑制作用是通过对活跃增殖的B或T淋巴细胞的作用介导的，尽管不能排除巨噬细胞的参与。
