卡介苗某些菌株对金黄仓鼠的毒力。
The virulence of some strains of BCG for golden hamsters.
作者信息
Bunch-Christensen K, Ladefoged A, Guld J
出版信息
Bull World Health Organ. 1968;39(5):821-8.
Although the injection of a large dose of BCG causes progressive, fatal disease in the Syrian golden hamster, not all BCG strains are equally active in this respect. It has been suggested that a strain to be used for vaccinating human beings should not be too weakly virulent in the hamster.Nine BCG strains, some of them widely used for BCG production, were compared with regard to their virulence for hamsters. Five of the strains were found to be of about the same high virulence; the other 4 were less virulent.Of the strains derived from the BCG that was used with success in the BCG trial conducted in Great Britain more than 15 years ago, some are more virulent for hamsters than others. It is suggested that virulence is easily lost but not gained when strains are maintained in vitro. Thus, less virulent strains would have deviated from the original protective strain, and for this reason may be less acceptable for vaccine production.
尽管注射大剂量卡介苗会在叙利亚金黄地鼠身上引发进行性的致命疾病，但并非所有卡介苗菌株在这方面的活性都相同。有人认为，用于人类疫苗接种的菌株在仓鼠体内的毒力不应过弱。对9种卡介苗菌株（其中一些广泛用于卡介苗生产）对仓鼠的毒力进行了比较。发现其中5种菌株具有大致相同的高毒力；另外4种毒力较弱。在15年多以前英国进行的卡介苗试验中成功使用的卡介苗衍生菌株中，有些对仓鼠的毒力比其他菌株更强。有人认为，当菌株在体外保存时，毒力很容易丧失但难以获得。因此，毒力较弱的菌株可能已偏离了原始的保护性菌株，出于这个原因，它们可能不太适合用于疫苗生产。
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