Ladefoged A, Bunch-Christensen K, Guld J
Bull World Health Organ. 1970;43(1):71-90.
The bank vole, like the guinea-pig, can be immunized against tuberculosis with very small doses of BCG, presumably because BCG is sufficiently virulent for both these species to multiply freely until the immunization of the animal has reached a maximum. Large doses of BCG induce an earlier, but not an ultimately stronger, immunity. However, the smallest immunizing dose is not the same for all BCG strains and this is a feature that may be used to differentiate strains. In the studies reported by the authors, the smallest immunizing dose for the bank vole was estimated for 11 BCG strains, some of them widely used in man. The results indicate potency ratios of 20: 1 between the strongest and the weakest strains. The ranking of strains in terms of the smallest immunizing dose was found to be correlated in most, but not in all, cases with a previously reported ranking of the lethal effects of the various strains in golden hamsters. The implications of these findings for production requirements and for reference preparations of BCG are discussed.
与豚鼠一样，用极少量的卡介苗就能使棕色田鼠对结核病产生免疫，大概是因为卡介苗对这两个物种都有足够的毒性，能在动物免疫达到最大值之前自由繁殖。大剂量的卡介苗能诱导更早的免疫，但最终的免疫效果并不更强。然而，并非所有卡介苗菌株的最小免疫剂量都相同，这一特性可用于区分菌株。在作者报告的研究中，估计了11种卡介苗菌株对棕色田鼠的最小免疫剂量，其中一些菌株在人类中广泛使用。结果表明，最强菌株与最弱菌株的效力比为20:1。发现根据最小免疫剂量对菌株进行的排名在大多数（但不是所有）情况下与先前报道的各种菌株对金黄仓鼠的致死作用排名相关。讨论了这些发现对卡介苗生产要求和参考制剂的影响。
