胆汁酸对大鼠肠道内毒素吸收的影响。
Effect of bile acids on the intestinal absorption of endotoxin in rats.
作者信息
Kocsár L T, Bertók L, Várterész V
出版信息
J Bacteriol. 1969 Oct;100(1):220-3. doi: 10.1128/jb.100.1.220-223.1969.
Abstract
The absorption of tritium-labeled Escherichia coli O89 Westphal-type endotoxin from the peritoneal cavity of rats was diminished by bile by 23% and by sodium deoxycholate by 47%, respectively. Practically, there is no endotoxin absorption from the intestinal tract of normal rats. The bile duct of rats was chronically cannulated for experimental purposes. A significant amount of perorally administered endotoxin absorbed from the intestinal canal into the blood in the rats treated thus. Absorption was demonstrated by the lethal effect of endotoxin on rats previously hypersensitized by lead acetate, and by the radioactivities found in the blood samples. The intestinal absorption of endotoxin in rats, rendered bile-deficient, may be prevented by sodium deoxycholate. Supported by their experimental findings, we emphasize the important role of bile acids in the defense mechanism of the macroorganism against bacterial endotoxins.
摘要
胆汁可使大鼠腹腔中氚标记的大肠杆菌O89韦斯特法尔型内毒素的吸收减少23%，脱氧胆酸钠则可使其减少47%。实际上，正常大鼠的肠道不会吸收内毒素。为进行实验，对大鼠的胆管进行了长期插管。在如此处理的大鼠中，经口给予的大量内毒素从肠道吸收进入血液。通过内毒素对先前经醋酸铅致敏的大鼠的致死作用以及血液样本中的放射性来证明吸收情况。脱氧胆酸钠可防止胆汁缺乏的大鼠肠道对内毒素的吸收。基于他们的实验结果，我们强调了胆汁酸在机体抵御细菌内毒素防御机制中的重要作用。
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