Blundell M R, Wild D G
Biochem J. 1969 Nov;115(2):207-12. doi: 10.1042/bj1150207.
Inhibition of the growth of Escherichia coli M.R.E. 600 by six different metal salts was accompanied by a greater decrease in the synthesis of RNA than in that of protein. The action of cobalt chloride was exceptional; inhibited cells made an excess of RNA to an extent depending on the concentration of Co(2+), the time of incubation and the concentration of Mg(2+) in the medium. Preferential synthesis of RNA in the presence of cobalt chloride was not confined to E. coli but occurred to various extents in some, but not all, of the other micro-organisms that were tested. Possible reasons for the special effect of Co(2+) are discussed.
六种不同金属盐对大肠杆菌M.R.E. 600生长的抑制作用伴随着RNA合成的减少幅度大于蛋白质合成的减少幅度。氯化钴的作用较为特殊;受抑制的细胞会过量合成RNA,其程度取决于Co(2+)的浓度、孵育时间以及培养基中Mg(2+)的浓度。在氯化钴存在的情况下RNA的优先合成并不局限于大肠杆菌,在所测试的其他一些(但并非全部)微生物中也不同程度地出现。文中讨论了Co(2+)产生特殊效应的可能原因。