大肠杆菌突变体中50S核糖体的一种异常前体。
An unusual precursor of 50S ribosomes in a mutant of Escherichia coli.
作者信息
Markey F, Wild D G
出版信息
Biochem J. 1976 Feb 15;154(2):311-8. doi: 10.1042/bj1540311.
Abstract
Escherichia coli strain 15-28 is a mutant with a defect in ribosome synthesis that leads to the accumulation of large amounts of ribonucleoprotein ("47S") particles during exponential growth. These particles are precursors to 50S ribosomes, but are distinct from precursors detected by pulse-labelling of the parent strain and also from ribosome precursors that accumulate during inhibition of growth by CoC12. Either ribosome assembly in the mutant differs from that in the wild-type strain, or 47S particles represent a hitherto unstudied stage in the synthesis of 50S ribosomes.
摘要
大肠杆菌菌株15 - 28是一种核糖体合成存在缺陷的突变体，这导致其在指数生长期间积累大量核糖核蛋白（“47S”）颗粒。这些颗粒是50S核糖体的前体，但与通过对亲本菌株进行脉冲标记检测到的前体不同，也与在CoC12抑制生长期间积累的核糖体前体不同。要么该突变体中的核糖体组装与野生型菌株不同，要么47S颗粒代表了50S核糖体合成中一个迄今未被研究的阶段。
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