利福平抑制大肠杆菌后核糖体的改变。
Altered ribosomes after inhibition of Escherichia coli by rifampicin.
作者信息
Blundell M R, Wild D G
出版信息
Biochem J. 1971 Feb;121(3):391-8. doi: 10.1042/bj1210391.
Abstract
Addition of rifampicin to growing cells of Escherichia coli affected the ribosomes. The polyribosomes first decayed to 70S ribosomes. These later dissociated to particles distinct from ribosomal subunits. The altered ribosomes sedimented more slowly than the corresponding subunits and had lost some protein; their ribosomal RNA was intact, but they were more susceptible to degradation by ribonuclease than normal ribosomes. The addition of rifampicin to preparations of lysed cells caused no detectable changes in the ribosome fraction.
摘要
向生长中的大肠杆菌细胞添加利福平会影响核糖体。多核糖体首先降解为70S核糖体。这些70S核糖体随后解离成与核糖体亚基不同的颗粒。改变后的核糖体沉降速度比相应的亚基慢，并且失去了一些蛋白质；它们的核糖体RNA是完整的，但比正常核糖体更容易被核糖核酸酶降解。向裂解细胞制剂中添加利福平对核糖体部分没有可检测到的变化。
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