近交犬群中的组织相容性研究。I. 白细胞群抗原对未修饰宿主同种异体肾移植存活的影响。
Histocompatibility studies in a closely bred colony of dogs. I. Influence of leukocyte group antigens upon renal allograft survival in the unmodified host.
作者信息
Rapaport F T, Hanaoka T, Shimada T, Cannon F D, Ferrebee J W
出版信息
J Exp Med. 1970 May 1;131(5):881-93. doi: 10.1084/jem.131.5.881.
Abstract
The establishment of a closely bred colony of beagles with known leukocyte group phenotypes has permitted an assessment of the role of leukocyte group antigens in conditioning the survival of renal allografts in the unmodified host. 22 kidney transplants obtained from leukocyte group-compatible donors were accorded a mean survival time of 25.5 days, as compared with 13.1 days for 27 transplants obtained from incompatible donors. Donor-recipient coefficients of correlation and Swisher erythrocyte group incompatibilities did not appear to affect the observed results. The mean survival time of 21 renal allografts performed in randomly selected mongrel dogs was 9.5 days. Availability of a carefully characterized and phenotyped canine population may be useful in further studies of the comparative immunogenicity of the major transplantable organs, and of methods designed to facilitate prolonged organ transplant survival in the mammalian host.
摘要
通过建立具有已知白细胞组表型的近亲繁殖比格犬群体，得以评估白细胞组抗原在未修饰宿主中对肾移植存活情况的影响。从白细胞组相容供体获得的22例肾移植的平均存活时间为25.5天，相比之下，从不相容供体获得的27例移植的平均存活时间为13.1天。供体 - 受体相关系数和斯威舍红细胞组不相容性似乎并未影响观察结果。在随机选择的杂种犬中进行的21例肾移植的平均存活时间为9.5天。拥有经过仔细特征化和表型分析的犬类群体，可能有助于进一步研究主要可移植器官的比较免疫原性，以及旨在促进哺乳动物宿主中器官移植长期存活的方法。
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Cross-reactions to skin homografts in man.人类对皮肤同种移植的交叉反应。
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