大肠杆菌中4-氨基苯甲酸的生物合成
Biosynthesis of 4-aminobenzoate in Escherichia coli.
作者信息
Huang M, Gibson F
出版信息
J Bacteriol. 1970 Jun;102(3):767-73. doi: 10.1128/jb.102.3.767-773.1970.
Abstract
Two different mutations (pabA and pabB) affecting 4-aminobenzoate biosynthesis were obtained in strains of Escherichia coli lacking chorismate mutase and anthranilate synthetase activity, thus allowing study of the pathway of biosynthesis of 4-aminobenzoate by use of cell extracts of strains carrying the pab mutations. Two components with approximate molecular weights of 9,000 (component A) and 48,000 (component B) are concerned in the biosynthesis of 4-aminobenzoate from chorismate by E. coli. No diffusible intermediate compound could be detected.
摘要
在缺乏分支酸变位酶和邻氨基苯甲酸合成酶活性的大肠杆菌菌株中，获得了两种影响4-氨基苯甲酸生物合成的不同突变（pabA和pabB），从而可以利用携带pab突变的菌株的细胞提取物来研究4-氨基苯甲酸的生物合成途径。大肠杆菌从分支酸生物合成4-氨基苯甲酸涉及两种分子量约为9000（组分A）和48000（组分B）的成分。未检测到可扩散的中间化合物。
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本文引用的文献
1
THE BIOSYNTHESIS OF p-AMINOBENZOIC ACID.对氨基苯甲酸的生物合成
Proc Natl Acad Sci U S A. 1959 Oct;45(10):1491-4. doi: 10.1073/pnas.45.10.1491.
2
Genetic Control of Biochemical Reactions in Neurospora.粗糙脉孢菌中生化反应的遗传控制。
Proc Natl Acad Sci U S A. 1941 Nov 15;27(11):499-506. doi: 10.1073/pnas.27.11.499.
3
Genetic Control of Biochemical Reactions in Neurospora: An "Aminobenzoicless" Mutant.粗糙脉孢菌中生化反应的遗传控制：一种“无对氨基苯甲酸”突变体。
Proc Natl Acad Sci U S A. 1942 Jun;28(6):234-43. doi: 10.1073/pnas.28.6.234.
4
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
5
[The biosynthesis of beta-galactosidase (lactase) in Escherichia coli; the specificity of induction].[大肠杆菌中β-半乳糖苷酶（乳糖酶）的生物合成；诱导的特异性]
Biochim Biophys Acta. 1951 Nov;7(4):585-99. doi: 10.1016/0006-3002(51)90072-8.
6
THE BIOSYNTHESIS OF PHENYLALANINE AND TYROSINE; ENZYMES CONVERTING CHORISMIC ACID INTO PREPHENIC ACID AND THEIR RELATIONSHIPS TO PREPHENATE DEHYDRATASE AND PREPHENATE DEHYDROGENASE.苯丙氨酸和酪氨酸的生物合成；将分支酸转化为预苯酸的酶及其与预苯酸脱水酶和预苯酸脱氢酶的关系。
Biochim Biophys Acta. 1965 Apr 12;100:76-88. doi: 10.1016/0304-4165(65)90429-0.
7
EFFECT OF INTEGRATED SEX FACTOR ON TRANSDUCTION OF CHROMOSOMAL GENES IN ESCHERICHIA COLI.整合性因子对大肠杆菌染色体基因转导的影响
J Bacteriol. 1965 Mar;89(3):680-6. doi: 10.1128/jb.89.3.680-686.1965.
8
THE GENETIC MAP OF ESCHERICHIA COLI K-12.大肠杆菌K-12的遗传图谱
Genetics. 1964 Oct;50(4):659-77. doi: 10.1093/genetics/50.4.659.
9
THE BIOSYNTHESIS OF P-AMINOBENZOIC ACID FROM CHORISMIC ACID.从分支酸合成对氨基苯甲酸
Biochim Biophys Acta. 1964 Mar 16;82:637-8. doi: 10.1016/0304-4165(64)90465-9.
10
The biosynthesis of p-aminobenzoic acid: studies on the origin of the amino group.对氨基苯甲酸的生物合成：氨基起源的研究
Biochim Biophys Acta. 1961 Aug 19;51:597-9. doi: 10.1016/0006-3002(61)90623-0.
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