Huang M, Gibson F
J Bacteriol. 1970 Jun;102(3):767-73. doi: 10.1128/jb.102.3.767-773.1970.
Two different mutations (pabA and pabB) affecting 4-aminobenzoate biosynthesis were obtained in strains of Escherichia coli lacking chorismate mutase and anthranilate synthetase activity, thus allowing study of the pathway of biosynthesis of 4-aminobenzoate by use of cell extracts of strains carrying the pab mutations. Two components with approximate molecular weights of 9,000 (component A) and 48,000 (component B) are concerned in the biosynthesis of 4-aminobenzoate from chorismate by E. coli. No diffusible intermediate compound could be detected.
在缺乏分支酸变位酶和邻氨基苯甲酸合成酶活性的大肠杆菌菌株中，获得了两种影响4-氨基苯甲酸生物合成的不同突变（pabA和pabB），从而可以利用携带pab突变的菌株的细胞提取物来研究4-氨基苯甲酸的生物合成途径。大肠杆菌从分支酸生物合成4-氨基苯甲酸涉及两种分子量约为9000（组分A）和48000（组分B）的成分。未检测到可扩散的中间化合物。
