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[新生儿百日咳口服免疫]

[Oral immunization of newborn infants against pertussis].

作者信息

Wiegl B, Meitinger C, van Thiel D, Janetschek R

出版信息

Monatsschr Kinderheilkd (1902). 1979 Jul;127(7):461-3.

PMID:492188
Abstract

A group of 148 newborn babies was subdivided into four groups. Subsequent to after oral application of killed pertussis bacteria (1-3 times; control) all developed agglutinating resp. precipitating antibodies. There was a clear relation between the given quantity of Oral Pertussis Vaccine and the antibody titer. The problem has been discussed, whether it will be possible to get a protection of newborn children against whooping cough within the first weeks of life and, simultaneously, to avoid side effects.

摘要

一组148名新生儿被分成四组。口服灭活百日咳杆菌(1 - 3次;对照组)后,所有人都产生了凝集反应或沉淀抗体。口服百日咳疫苗的给定剂量与抗体滴度之间存在明显关系。人们讨论了一个问题,即在新生儿生命的最初几周内是否有可能使其获得针对百日咳的保护,同时避免副作用。

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