Maurer H, Höfler K H, Hilbe W, Huber E G
Wien Klin Wochenschr. 1979 Nov 9;91(21):717-20.
A preliminary report is presented on oral vaccination against whooping cough. 23 babies younger than, and 2 older than nine weeks and 12 newborn infants were vaccinated orally. No side effects were observed. Serum antibody titres did not increase markedly, but no child was seronegative after vaccination. An evident antibody titre rise to a higher level than in serum was found in the saliva. These results point toward an adequate local immunity. At present a definite statement about the efficacy of this oral vaccination is difficult to make. Further investigations are necessary.
本文给出了关于百日咳口服疫苗接种的初步报告。对23名9周龄以下婴儿、2名9周龄以上婴儿以及12名新生儿进行了口服疫苗接种。未观察到副作用。血清抗体滴度没有明显升高，但接种疫苗后没有儿童血清学阴性。在唾液中发现抗体滴度明显升高至高于血清中的水平。这些结果表明有足够的局部免疫力。目前很难对这种口服疫苗的效果做出明确说明。需要进一步研究。
